Conflict of interest: The authors have no conflicts of interest to declare.
Double neuroendocrine ductal carcinomas in situ coexisting with a background of diffuse idiopathic neuroendocrine cell hyperplasia of breast: A case report and hypothesis of neuroendocrine tumor development
Article first published online: 14 FEB 2012
© 2012 The Authors. Pathology International © 2012 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd
Volume 62, Issue 5, pages 331–334, May 2012
How to Cite
Miura, K., Nasu, H. and Ogura, H. (2012), Double neuroendocrine ductal carcinomas in situ coexisting with a background of diffuse idiopathic neuroendocrine cell hyperplasia of breast: A case report and hypothesis of neuroendocrine tumor development. Pathology International, 62: 331–334. doi: 10.1111/j.1440-1827.2012.02786.x
- Issue published online: 24 APR 2012
- Article first published online: 14 FEB 2012
- Received 3 September 2011. Accepted for publication 20 December 2011.
- breast neoplasm;
- ductal carcinoma in situ;
- neuroendocrine cell tumor;
- somatostatin receptor
This article reports the case of a 72-year-old woman with two nodules of neuroendocrine (NE) ductal carcinoma in situ coexistent with a background of NE cell hyperplasia. Both tumors, 15 and 3 mm in size, were incidentally revealed on computed tomography without any apparent clinical symptoms. The tumors showed similar histological features, and more than 50% of the tumor cells patchily expressed NE markers, such as chromogranin A, synaptophysin, CD56, and somatostatin receptor type 2. The surrounding nontumor ductal cells also showed spotty or linear positivity for NE markers in contrast to the cells of normal atrophic breasts, which rarely present with NE cells. Moreover, focal mucin production was also observed in the peripheral ducts. It is hypothesized that idiopathic breast NE cell hyperplasia with multiple small nests of NE cells may extend to form a true mass of NE neoplasms.