Breast cancer pathology: The impact of molecular taxonomy on morphological taxonomy
Article first published online: 16 MAR 2012
© 2012 The Author. Pathology International © 2012 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd
Volume 62, Issue 5, pages 295–302, May 2012
How to Cite
Masuda, S. (2012), Breast cancer pathology: The impact of molecular taxonomy on morphological taxonomy. Pathology International, 62: 295–302. doi: 10.1111/j.1440-1827.2012.02790.x
- Issue published online: 24 APR 2012
- Article first published online: 16 MAR 2012
- Received 8 December 2011. Accepted for publication 25 December 2011.
- breast cancer;
- intrinsic subtype;
- molecular taxonomy;
- morphological taxonomy
The concept of having an ‘intrinsic subtype,’ or a molecular taxonomy, lets us clearly recognize that breast cancers have characteristically different patterns of gene expression, thus giving newfound significance to morphological taxonomy. In this review, the concept of the ‘intrinsic subtype’ is discussed, research questions are introduced to refine the significance of morphological taxonomy, and a corresponding example is presented between microarray analysis and ‘immunohistochemical subtype,’ or histological taxonomy.