Pulmonary sarcoidosis and antiphospholipid syndrome

Authors

  • Fumiyuki TAKAHASHI,

    Corresponding author
    1. Department of Respiratory Medicine,
    2. Research Institute for Diseases of Old Ages, Juntendo University, School of Medicine, Hongo, Bunkyo-Ku, Tokyo, and
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  • Michie TOBA,

    1. Department of Respiratory Medicine,
    2. Research Institute for Diseases of Old Ages, Juntendo University, School of Medicine, Hongo, Bunkyo-Ku, Tokyo, and
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  • Kazuhisa TAKAHASHI,

    1. Department of Respiratory Medicine,
    2. Research Institute for Diseases of Old Ages, Juntendo University, School of Medicine, Hongo, Bunkyo-Ku, Tokyo, and
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  • Shigeru TOMINAGA,

    1. Department of Respiratory Medicine,
    2. Research Institute for Diseases of Old Ages, Juntendo University, School of Medicine, Hongo, Bunkyo-Ku, Tokyo, and
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  • Koichi SATO,

    1. Department of Respiratory Medicine,
    2. Research Institute for Diseases of Old Ages, Juntendo University, School of Medicine, Hongo, Bunkyo-Ku, Tokyo, and
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  • Yoshiteru MORIO,

    1. Department of Respiratory Medicine,
    2. Research Institute for Diseases of Old Ages, Juntendo University, School of Medicine, Hongo, Bunkyo-Ku, Tokyo, and
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  • Yuta NAKAO,

    1. Department of Respiratory Medicine,
    2. Research Institute for Diseases of Old Ages, Juntendo University, School of Medicine, Hongo, Bunkyo-Ku, Tokyo, and
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  • Ken TAJIMA,

    1. Department of Respiratory Medicine,
    2. Research Institute for Diseases of Old Ages, Juntendo University, School of Medicine, Hongo, Bunkyo-Ku, Tokyo, and
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  • Kayo MIURA,

    1. Department of Respiratory Medicine,
    2. Research Institute for Diseases of Old Ages, Juntendo University, School of Medicine, Hongo, Bunkyo-Ku, Tokyo, and
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  • Toshimasa UEKUSA,

    1. Department of Laboratory, Kanto Rousai Hospital, Sumiyoshi-Cho Kizuki, Nakahara-Ku, Kawasaki-Shi, Kanagawa, Japan
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  • Yoshinosuke FUKUCHI

    1. Department of Respiratory Medicine,
    2. Research Institute for Diseases of Old Ages, Juntendo University, School of Medicine, Hongo, Bunkyo-Ku, Tokyo, and
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Fumiyuki Takahashi, Department of Respiratory Medicine; Juntendo University, School of Medicine, 2-1-1 Hongo; Bunkyo-Ku, Tokyo 113-8421, Japan. Email: fumiyuki@med.juntendo.ac.jp

Abstract

Abstract:  Various autoimmune diseases have been reported to occur in patients with sarcoidosis. However, coexistence of sarcoidosis and antiphospholipid syndrome (APS) is extremely rare. We describe a 59-year-old female patient with pulmonary sarcoidosis who had preceding APS. Her previous medical history consisted of a miscarriage and ischemic colitis. She was diagnosed as APS during the onset of a brainstem infarction with positive reaction to β2-glycoprotein I-dependent anticardiolipin antibody. Two years later, chest CT revealed enlargement of the hilar and mediastinal lymph nodes and small nodules in the lung fields. Transbronchial lung biopsy demonstrated non-caseating epithelioid cell granuloma leading to the diagnosis of definite pulmonary sarcoidosis. This is the first APS case where pulmonary involvement with sarcoidosis has been confirmed through lung biopsy. Our case report suggests that APS should be recognized as an accompanying disorder of sarcoidosis.

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