Inflammatory lesions of the lung, submandibular gland, bile duct and prostate in a patient with IgG4-associated multifocal systemic fibrosclerosis
Article first published online: 26 MAY 2007
Volume 12, Issue 3, pages 455–457, May 2007
How to Cite
HAMED, G., TSUSHIMA, K., YASUO, M., KUBO, K., YAMAZAKI, S., KAWA, S., HAMANO, H. and YAMAMOTO, H. (2007), Inflammatory lesions of the lung, submandibular gland, bile duct and prostate in a patient with IgG4-associated multifocal systemic fibrosclerosis. Respirology, 12: 455–457. doi: 10.1111/j.1440-1843.2007.01053.x
- Issue published online: 26 MAY 2007
- Article first published online: 26 MAY 2007
- Received 19 October 2005; invited to revise 1 December 2005; revised 22 December 2005; accepted 5 January 2006 (Associate Editor: Kwun Fong).
- IgG4-positive plasma cell;
- multifocal systemic fibrosclerosis;
- solid nodule;
- submandibular gland
Abstract: Multifocal systemic fibrosclerosis (MSF) is a multisystem disease, which often mimics malignancy. A 70-year-old asymptomatic man with lesions in the lung, prostate, submandibular glands and bile ducts appeared to have malignancy. Biopsy of a lung nodule showed IgG4-positive plasma cell infiltration and the serum IgG4 was elevated. A diagnosis of MSF was made and the patient treated with oral prednisolone at 1 mg/kg/day. Sclerosing cholangitis, retroperitoneal fibrosis, Riedel’s thyroiditis, fibrotic pseudotumor of the orbit and fibrosis of the salivary glands have all been reported to be part of this disease. It is now necessary for MSF to be considered in patients with pulmonary lesions mimicking lung cancer.