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Fractional exhaled nitric oxide in asthma: an update

  1. Alessandra SANDRINI1,
  2. D. Robin TAYLOR4,
  3. Paul S. THOMAS2,3,
  4. Deborah H. YATES1,*

Article first published online: 16 SEP 2009

DOI: 10.1111/j.1440-1843.2009.01616.x

Issue

Respirology

Respirology

Volume 15, Issue 1, pages 57–70, January 2010

Additional Information

How to Cite

SANDRINI, A., TAYLOR, D. R., THOMAS, P. S. and YATES, D. H. (2010), Fractional exhaled nitric oxide in asthma: an update. Respirology, 15: 57–70. doi: 10.1111/j.1440-1843.2009.01616.x

Author Information

  1. 1

    Department of Thoracic Medicine, St Vincent's Hospital, and

  2. 2

    Centre for Infection and Inflammation Research, School of Medical Sciences and Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney and

  3. 3

    Department of Respiratory Medicine, Prince of Wales Hospital, Randwick, Australia, and

  4. 4

    Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand

*Dr Deborah H. Yates, Department of Thoracic Medicine, St Vincent's Hospital, Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia. Email: deborahy88@hotmail.com

Publication History

  1. Issue published online: 27 DEC 2009
  2. Article first published online: 16 SEP 2009
  3. Received 6 May 2009; invited to revise 14 May 2009; revised 8 June 2009; accepted 16 June 2009 (Associate Editor: Fan Chung).Senior Editor sign off date: Ian Yang 18 June 2009.

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Keywords:

  • airway inflammation;
  • asthma;
  • eosinophilic inflammation;
  • eosinophil;
  • inhaled steroid;
  • non-invasive monitoring

ABSTRACT

In asthma, clinical symptoms and lung function are insensitive in reflecting the underlying airway inflammation, and monitoring of this process has only recently become available. Fractional exhaled nitric oxide (FeNO) is now recognized as a reliable surrogate marker of eosinophilic airway inflammation and offers the advantage of being completely non-invasive and very easy to obtain. This review summarizes the clinical use of FeNO in asthma. It covers the relationship between FeNO and the underlying eosinophilic inflammation, the pathophysiology and production of FeNO, technical aspects of FeNO measurement and potential confounding factors in interpreting levels. FeNO reference values and the role of FeNO in asthma assessment, diagnosis and management are also discussed.

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