Multiple tiny granulomatous lesions with eosinophils in a patient with smoldering-type adult T-cell leukaemia: The possibility of a new type of bronchioloalveolopathy

  1. Hiroshi ISHII1,*,
  2. Yoshinori KAWABATA3,
  3. Yuka AMEMIYA1,
  4. Masao OGATA2,
  5. Jun-ichi KADOTA1,2

Article first published online: 5 NOV 2009

DOI: 10.1111/j.1440-1843.2009.01646.x

Issue

Respirology

Respirology

Volume 15, Issue 1, pages 182–184, January 2010

Additional Information

How to Cite

ISHII, H., KAWABATA, Y., AMEMIYA, Y., OGATA, M. and KADOTA, J.-i. (2010), Multiple tiny granulomatous lesions with eosinophils in a patient with smoldering-type adult T-cell leukaemia: The possibility of a new type of bronchioloalveolopathy. Respirology, 15: 182–184. doi: 10.1111/j.1440-1843.2009.01646.x

Author Information

  1. 1

    Departments of Respiratory Medicine and

  2. 2

    Haematology, Oita University Hospital, Oita, and

  3. 3

    Division of Pathology, Saitama Cardiovascular and Respiratory Centre, Saitama, Japan

*Hiroshi Ishii, Department of Respiratory Medicine, Oita University Hospital, Idaigaoka, Yufu-city, Oita 879-5593, Japan. Email: hishii@med.oita-u.ac.jp

Publication History

  1. Issue published online: 27 DEC 2009
  2. Article first published online: 5 NOV 2009
  3. Received 5 September 2008; invited to revise 15 October 2008; revised 19 October 2008; accepted 20 October 2008 (Associate Editor: Jeffrey Swigris).

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Keywords:

  • bronchioloalveolopathy;
  • coagulation necrosis;
  • human T-lymphotropic virus type-1

ABSTRACT

We herein describe the first case, to our knowledge, of pulmonary lesions characterized by necrotizing granuloma formation with eosinophils, in a patient with smoldering-type adult T-cell leukaemia. A 74-year-old man, diagnosed with smoldering-type adult T-cell leukaemia 1 year previously, was admitted due to repeated pyrexia and concurrent identification of diffuse small pulmonary nodules. A surgical lung biopsy specimen revealed inflammatory nodular lesions measuring up to 3 mm in size, which contained necrotizing and non-necrotizing granulomas, intraluminar organization and eosinophils, and were of unknown aetiology. The patient's condition, including the radiological findings, improved gradually without any treatment. This case suggests the possibility of a new type of human T-lymphotropic virus type-1 associated bronchioloalveolar disorder.

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