Asthma and insulin resistance in children
Article first published online: 23 APR 2010
© 2010 The Authors. Journal compilation © 2010 Asian Pacific Society of Respirology
Volume 15, Issue 5, pages 779–784, July 2010
How to Cite
ARSHI, M., CARDINAL, J., HILL, R. J., DAVIES, P. S.W. and WAINWRIGHT, C. (2010), Asthma and insulin resistance in children. Respirology, 15: 779–784. doi: 10.1111/j.1440-1843.2010.01767.x
- Issue published online: 21 JUN 2010
- Article first published online: 23 APR 2010
- Received 11 June 2009; invited to revise 13 August 2009; revised 2 January 2010; accepted 1 February 2010 (Associate Editor: Darryl Knight).
- body mass index;
- insulin resistance;
Background and objective: Increased BMI is a risk factor for asthma in children and may be related to adipokines. Adipokines affect insulin-stimulated glucose uptake in vitro but, to date there is little evidence for such a role in vivo. We explored relationships between obesity and allergic asthma in children.
Methods: Twenty-one allergic asthmatics (AA) and 10 non-allergic healthy controls, aged 6–17.9 years were studied. AA group included children with a positive mannitol challenge test, >25 ppb of exhaled nitric oxide and a positive skin prick test. BMI z-scores were calculated. Blood levels of insulin, glucose, leptin, resistin, tumour necrosis factor-α, IL-4, IL-5 and IL-6 were measured. Insulin resistance (IR) was estimated using the homeostasis model assessment (HOMA).
Results: There was no significant difference in BMI z-scores between AA and healthy controls (mean: 0.01 vs −0.10). However, significant differences were found in the blood levels of IL-6 (P = 0.05), IL-4 (P = 0.04), IL-5 (P = 0.01) and leptin (P = 0.02). IR was only found in the AA group (42.85%). Homeostasis model assessment insulin resistance (HOMA-IR) was significantly related to IL-6 (r = 0.44, P = 0.05) and tumour necrosis factor-α (r = −0.45, P = 0.05).
Conclusions: IR was observed in AA. Our findings are suggestive of a complex interaction between the inflammatory state and adiposity, allergy and asthma.