The Authors: Kevin Looi is a PhD student at the University of Western Australia investigating epithelial barrier disruption post injury. Erika Sutanto is a Senior Researcher with expertise and interest in airway epithelial responses to injury in children with cystic fibrosis. Balarka Banerjee is a PhD student at the University of Western Australia investigating the processes leading to lung transplant rejection. Luke Garratt is a PhD student at the University of Western Australia investigating epithelial wound repair in children with cystic fibrosis. Kak-Ming Ling is a research scientist investigating aspects of dysregulated epithelial repair in children with asthma. Clara Foo is a PhD student at the University of Western Australia investigating innate immune responses of the airway epithelium post injury in children with cystic fibrosis. Stephen Stick is an NHMRC Practitioner Fellow and respiratory physician with a long-standing interest in paediatric airway disease. Anthony Kicic is a Senior Research Officer with expertise in functional airway epithelial studies.
Bronchial brushings for investigating airway inflammation and remodelling
Article first published online: 28 JUN 2011
© 2011 The Authors; Respirology © 2011 Asian Pacific Society of Respirology
Volume 16, Issue 5, pages 725–737, July 2011
How to Cite
LOOI, K., SUTANTO, E. N., BANERJEE, B., GARRATT, L., LING, K.-M., FOO, C. J., STICK, S. M. and KICIC, A. (2011), Bronchial brushings for investigating airway inflammation and remodelling. Respirology, 16: 725–737. doi: 10.1111/j.1440-1843.2011.02001.x
Authors contributed equally to this manuscript.
- Issue published online: 28 JUN 2011
- Article first published online: 28 JUN 2011
- Accepted manuscript online: 30 MAY 2011 02:58AM EST
- Received 1 April 2011; invited to revise 3 May 2011; revised 5 May 2011; accepted 21 May 2011.
- airway inflammation;
- cytology brushing;
- functional study
Asthma is the commonest medical cause for hospital admission for children in Australia, affects more than 300 million people worldwide, and is incurable, severe in large number and refractory to treatment in many. However, there have been no new significant treatments despite intense research and billions of dollars. The advancement in our understanding in this disease has been limited due to its heterogeneity, genetic complexity and has severely been hampered particularly in children by the difficulty in obtaining relevant target organ tissue. This review attempts to provide an overview of the currently used and recently developed/adapted techniques used to obtain lung tissue with specific reference to the airway epithelium.