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REFERENCES

  • 1
    Hotchkiss JW, Reid SW, Christley RM. A survey of horse owners in Great Britain regarding horses in their care. Part 2: risk factors for recurrent airway obstruction. Equine Vet. J. 2007; 39: 3018.
  • 2
    Bouley H. In: Raige-Delorme MM, Daremberg C, Bouley H et al. (eds) Nouveau dictionnaire lexicographique et descriptif des sciences médicales et vétérinaires. Asselin, Paris, 1863; 10734.
  • 3
    Lowell FC. Observations on heaves. An asthma-like syndrome in the horse. J. Allergy Clin. Immunol. 1964; 35: 32230.
  • 4
    Seahorn TL, Groves MG, Harrington KS et al. Chronic obstructive pulmonary disease in horses in Louisiana. J. Am. Vet. Med. Assoc. 1996; 208: 24851.
  • 5
    Seahorn TL, Beadle RE. Summer pasture-associated obstructive pulmonary disease in horses: 21 cases (1983–1991). J. Am. Vet. Med. Assoc. 1993; 202: 77982.
  • 6
    Costa LR, Johnson JR, Baur ME et al. Temporal clinical exacerbation of summer pasture-associated recurrent airway obstruction and relationship with climate and aeroallergens in horses. Am. J. Vet. Res. 2006; 67: 163542.
  • 7
    Derksen FJ, Robinson NE, Berney CE. Aerosol pirbuterol: bronchodilator activity and side effects in ponies with recurrent airway obstruction (heaves). Equine Vet. J. 1992; 24: 10712.
  • 8
    Broadstone RV, Scott JS, Derksen FJ et al. Effects of atropine in ponies with recurrent airway obstruction. J. Appl. Physiol. 1988; 65: 27205.
  • 9
    Robinson NE, Derksen FJ, Berney C et al. The airway response of horses with recurrent airway obstruction (heaves) to aerosol administration of ipratropium bromide. Equine Vet. J. 1993; 25: 299303.
  • 10
    Miskovic M, Couetil LL, Thompson CA. Lung function and airway cytologic profiles in horses with recurrent airway obstruction maintained in low-dust environments. J. Vet. Intern. Med. 2007; 21: 10606.
  • 11
    Robinson NE. International workshop on equine chronic airway disease. Michigan State University 16–18 June 2000. Equine Vet. J. 2001; 33: 519.
  • 12
    Breeze RG. Heaves. The problem of disease definition. Vet. Clin. North Am. Large Anim. Pract. 1979; 1: 21930.
  • 13
    McPherson EA, Thomson JR. Chronic obstructive pulmonary disease in the horse. 1: nature of the disease. Equine Vet. J. 1983; 15: 2036.
  • 14
    Couetil LL, Hoffman AM, Hodgson J et al. Inflammatory airway disease of horses. J. Vet. Intern. Med. 2007; 21: 35661.
  • 15
    Lavoie JP, Cesarini C, Lavoie-Lamoureux A et al. Bronchoalveolar lavage fluid cytology and cytokine messenger ribonucleic acid expression of racehorses with exercise intolerance and lower airway inflammation. J. Vet. Intern. Med. 2011; 25: 3229.
  • 16
    Anderson GP. Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet 2008; 372: 110719.
  • 17
    Hotchkiss JW, Reid SW, Christley R. Construction and validation of a risk-screening questionnaire for the investigation of recurrent airway obstruction in epidemiological studies of horse populations in Great Britain. Prev. Vet. Med. 2006; 75: 821.
  • 18
    Marti E, Gerber H, Essich G et al. The genetic basis of equine allergic diseases. 1. Chronic hypersensitivity bronchitis. Equine Vet. J. 1991; 23: 45760.
  • 19
    McPherson EA, Lawson GH, Murphy JR et al. Chronic obstructive pulmonary disease (COPD): factors influencing the occurrence. Equine Vet. J. 1979; 11: 16771.
  • 20
    Ramseyer A, Gaillard C, Burger D et al. Effects of genetic and environmental factors on chronic lower airway disease in horses. J. Vet. Intern. Med. 2007; 21: 14956.
  • 21
    Ewart SL, Robinson NE. Genes and respiratory disease: a first step on a long journey. Equine Vet. J. 2007; 39: 2704.
  • 22
    Solberg OD, Jackson KA, Millon LV et al. Genomic characterization of equine interleukin-4 receptor alpha-chain (IL4R). Vet. Immunol. Immunopathol. 2004; 97: 18794.
  • 23
    Jost U, Klukowska-Rotzler J, Dolf G et al. A region on equine chromosome 13 is linked to recurrent airway obstruction in horses. Equine Vet. J. 2007; 39: 23641.
  • 24
    Risma KA, Wang N, Andrews RP et al. V75R576 IL-4 receptor alpha is associated with allergic asthma and enhanced IL-4 receptor function. J. Immunol. 2002; 169: 160410.
  • 25
    Hershey GK, Friedrich MF, Esswein LA et al. The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N. Engl. J. Med. 1997; 337: 17205.
  • 26
    Neuhaus S, Bruendler P, Frey CF et al. Increased parasite resistance and recurrent airway obstruction in horses of a high-prevalence family. J. Vet. Intern. Med. 2010; 24: 40713.
  • 27
    Brundler P, Frey CF, Gottstein B et al. Lower shedding of strongylid eggs by Warmblood horses with recurrent airway obstruction compared to unrelated healthy horses. Vet. J. 2011; doi: S1090-0233(11)00003-7 [pii] 10.1016/j.tvjl.2010.12.029 (Epub ahead of print).
  • 28
    Barnes KC, Grant AV, Gao P. A review of the genetic epidemiology of resistance to parasitic disease and atopic asthma: common variants for common phenotypes? Curr. Opin. Allergy Clin. Immunol. 2005; 5: 37985.
  • 29
    Martinez FD. Respiratory syncytial virus bronchiolitis and the pathogenesis of childhood asthma. Pediatr. Infect. Dis. J. 2003; 22: S7682.
  • 30
    McGorum BC, Dixon PM, Halliwell RE. Responses of horses affected with chronic obstructive pulmonary disease to inhalation challenges with mould antigens. Equine Vet. J. 1993; 25: 2617.
  • 31
    McGorum BC, Dixon PM, Halliwell RE. Evaluation of intradermal mould antigen testing in the diagnosis of equine chronic obstructive pulmonary disease. Equine Vet. J. 1993; 25: 2735.
  • 32
    McPherson EA, Lawson GH, Murphy JR et al. Chronic obstructive pulmonary disease (COPD) in horses: aetiological studies: responses to intradermal and inhalation antigenic challenge. Equine Vet. J. 1979; 11: 15966.
  • 33
    Jose-Cunilleras E, Kohn CW, Hillier A et al. Intradermal testing in healthy horses and horses with chronic obstructive pulmonary disease, recurrent urticaria, or allergic dermatitis. J. Am. Vet. Med. Assoc. 2001; 219: 111521.
  • 34
    Tahon L, Baselgia S, Gerber V et al. In vitro allergy tests compared to intradermal testing in horses with recurrent airway obstruction. Vet. Immunol. Immunopathol. 2009; 127: 8593.
  • 35
    Eder C, Crameri R, Mayer C et al. Allergen-specific IgE levels against crude mould and storage mite extracts and recombinant mould allergens in sera from horses affected with chronic bronchitis. Vet. Immunol. Immunopathol. 2000; 73: 24153.
  • 36
    Kunzle F, Gerber V, Van Der Haegen A et al. IgE-bearing cells in bronchoalveolar lavage fluid and allergen-specific IgE levels in sera from RAO-affected horses. J. Vet. Med. A Physiol. Pathol. Clin. Med. 2007; 54: 407.
  • 37
    Scharrenberg A, Gerber V, Swinburne JE et al. IgE, IgGa, IgGb and IgG(T) serum antibody levels in offspring of two sires affected with equine recurrent airway obstruction. Anim. Genet. 2010; 41(Suppl. 2): 1317.
  • 38
    Moran G, Burgos R, Araya O et al. In vitro bioassay to detect reaginic antibodies from the serum of horses affected with recurrent airway obstruction. Vet. Res. Commun. 2010; 34: 919.
  • 39
    Moran G, Folch H, Araya O et al. Detection of reaginic antibodies against Faenia rectivirgula from the serum of horses affected with Recurrent Airway Obstruction by an in vitro bioassay. Vet. Res. Commun. 2010; 34: 71926.
  • 40
    Schmallenbach KH, Rahman I, Sasse HH et al. Studies on pulmonary and systemic Aspergillus fumigatus-specific IgE and IgG antibodies in horses affected with chronic obstructive pulmonary disease (COPD). Vet. Immunol. Immunopathol. 1998; 66: 24556.
  • 41
    Halliwell RE, McGorum BC, Irving P et al. Local and systemic antibody production in horses affected with chronic obstructive pulmonary disease. Vet. Immunol. Immunopathol. 1993; 38: 20115.
  • 42
    Eder C, Curik I, Brem G et al. Influence of environmental and genetic factors on allergen-specific immunoglobulin-E levels in sera from Lipizzan horses. Equine Vet. J. 2001; 33: 71420.
  • 43
    Powe DG, Bonnin AJ, Jones NS. ‘Entopy’: local allergy paradigm. Clin. Exp. Allergy 2010; 40: 98797.
  • 44
    Barnes PJ. Intrinsic asthma: not so different from allergic asthma but driven by superantigens? Clin. Exp. Allergy 2009; 39: 114551.
  • 45
    Mouthuy J, Detry B, Sohy C et al. Presence in sputum of functional dust mite-specific IgE antibodies in intrinsic asthma. Am. J. Respir. Crit. Care Med. 2011; 184: 20614.
  • 46
    Deaton CM, Deaton L, Jose-Cunilleras E et al. Early onset airway obstruction in response to organic dust in the horse. J. Appl. Physiol. 2007; 102: 10717.
  • 47
    Hare JE, Viel L, Conlon PD et al. In vitro allergen-induced degranulation of pulmonary mast cells from horses with recurrent airway obstruction (heaves). Am. J. Vet. Res. 1999; 60: 8417.
  • 48
    McGorum BC, Dixon PM, Halliwell RE. Quantification of histamine in plasma and pulmonary fluids from horses with chronic obstructive pulmonary disease, before and after ‘natural (hay and straw) challenges. Vet. Immunol. Immunopathol. 1993; 36: 22337.
  • 49
    Dacre KJ, McGorum BC, Marlin DJ et al. Organic dust exposure increases mast cell tryptase in bronchoalveolar lavage fluid and airway epithelium of heaves horses. Clin. Exp. Allergy 2007; 37: 180918.
  • 50
    van der Haegen A, Kunzle F, Gerber V et al. Mast cells and IgE-bearing cells in lungs of RAO-affected horses. Vet. Immunol. Immunopathol. 2005; 108: 32534.
  • 51
    Wagner B. IgE in horses: occurrence in health and disease. Vet. Immunol. Immunopathol. 2009; 132: 2130.
  • 52
    Dales RE, Munt PW. Farmer's lung disease. Can. Fam. Physician 1982; 28: 181720.
  • 53
    Lawson GH, McPherson EA, Murphy JR et al. The presence of precipitating antibodies in the sera of horses with chronic obstructive pulmonary disease (COPD). Equine Vet. J. 1979; 11: 1726.
  • 54
    Lavoie JP, Maghni K, Desnoyers M et al. Neutrophilic airway inflammation in horses with heaves is characterized by a Th2-type cytokine profile. Am. J. Respir. Crit. Care Med. 2001; 164: 141013.
  • 55
    Cordeau ME, Joubert P, Dewachi O et al. IL-4, IL-5 and IFN-gamma mRNA expression in pulmonary lymphocytes in equine heaves. Vet. Immunol. Immunopathol. 2004; 97: 8796.
  • 56
    Kleiber C, McGorum BC, Horohov DW et al. Cytokine profiles of peripheral blood and airway CD4 and CD8 T lymphocytes in horses with recurrent airway obstruction. Vet. Immunol. Immunopathol. 2005; 104: 917.
  • 57
    Bowles KS, Beadle RE, Mouch S et al. A novel model for equine recurrent airway obstruction. Vet. Immunol. Immunopathol. 2002; 87: 3859.
  • 58
    Ainsworth DM, Grunig G, Matychak MB et al. Recurrent airway obstruction (RAO) in horses is characterized by IFN-gamma and IL-8 production in bronchoalveolar lavage cells. Vet. Immunol. Immunopathol. 2003; 96: 8391.
  • 59
    Giguere S, Viel L, Lee E et al. Cytokine induction in pulmonary airways of horses with heaves and effect of therapy with inhaled fluticasone propionate. Vet. Immunol. Immunopathol. 2002; 85: 14758.
  • 60
    Beadle RE, Horohov DW, Gaunt SD. Interleukin-4 and interferon-gamma gene expression in summer pasture-associated obstructive pulmonary disease affected horses. Equine Vet. J. 2002; 34: 38994.
  • 61
    Horohov DW, Beadle RE, Mouch S et al. Temporal regulation of cytokine mRNA expression in equine recurrent airway obstruction. Vet. Immunol. Immunopathol. 2005; 108: 23745.
  • 62
    Desjardins I, Theoret C, Joubert P et al. Comparison of TGF-beta 1 concentrations in bronchoalveolar fluid of horses affected with heaves and of normal controls. Vet. Immunol. Immunopathol. 2004; 101: 13341.
  • 63
    Debrue M, Hamilton E, Joubert P et al. Chronic exacerbation of equine heaves is associated with an increased expression of interleukin-17 mRNA in bronchoalveolar lavage cells. Vet. Immunol. Immunopathol. 2005; 105: 2531.
  • 64
    Ainsworth DM, Wagner B, Franchini M et al. Time-dependent alterations in gene expression of interleukin-8 in the bronchial epithelium of horses with recurrent airway obstruction. Am. J. Vet. Res. 2006; 67: 66977.
  • 65
    El Biaze M, Boniface S, Koscher V et al. T cell activation, from atopy to asthma: more a paradox than a paradigm. Allergy 2003; 58: 84453.
  • 66
    Magnan AO, Mely LG, Camilla CA et al. Assessment of the Th1/Th2 paradigm in whole blood in atopy and asthma. Increased IFN-gamma-producing CD8(+) T cells in asthma. Am. J. Respir. Crit. Care Med. 2000; 161: 17906.
  • 67
    Bettiol J, Bartsch P, Louis R et al. Cytokine production from peripheral whole blood in atopic and nonatopic asthmatics: relationship with blood and sputum eosinophilia and serum IgE levels. Allergy 2000; 55: 113441.
  • 68
    Al-Ramli W, Prefontaine D, Chouiali F et al. T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma. J. Allergy Clin. Immunol. 2009; 123: 11857.
  • 69
    Cosmi L, Maggi L, Santarlasci V et al. Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4. J. Allergy Clin. Immunol. 2010; 125: 22230. e1-4.
  • 70
    McGorum BC, Ellison J, Cullen RT. Total and respirable airborne dust endotoxin concentrations in three equine management systems. Equine Vet. J. 1998; 30: 4304.
  • 71
    Berndt A, Derksen FJ, Edward Robinson N. Endotoxin concentrations within the breathing zone of horses are higher in stables than on pasture. Vet. J. 2010; 183: 547.
  • 72
    Michel O, Kips J, Duchateau J et al. Severity of asthma is related to endotoxin in house dust. Am. J. Respir. Crit. Care Med. 1996; 154: 16416.
  • 73
    Rylander R, Haglind P, Lundholm M. Endotoxin in cotton dust and respiratory function decrement among cotton workers in an experimental cardroom. Am. Rev. Respir. Dis. 1985; 131: 20913.
  • 74
    Olenchock SA, May JJ, Pratt DS et al. Occupational exposures to airborne endotoxins in agriculture. Prog. Clin. Biol. Res. 1987; 231: 47587.
  • 75
    Michel O, Duchateau J, Sergysels R. Effect of inhaled endotoxin on bronchial reactivity in asthmatic and normal subjects. J. Appl. Physiol. 1989; 66: 105964.
  • 76
    Pirie RS, Dixon PM, Collie DD et al. Pulmonary and systemic effects of inhaled endotoxin in control and heaves horses. Equine Vet. J. 2001; 33: 31118.
  • 77
    Pirie RS, Collie DD, Dixon PM et al. Inhaled endotoxin and organic dust particulates have synergistic proinflammatory effects in equine heaves (organic dust-induced asthma). Clin. Exp. Allergy 2003; 33: 67683.
  • 78
    Pirie RS, Dixon PM, McGorum BC. Endotoxin contamination contributes to the pulmonary inflammatory and functional response to Aspergillus fumigatus extract inhalation in heaves horses. Clin. Exp. Allergy 2003; 33: 128996.
  • 79
    Sandersen C, Bureau F, Turlej R et al. p65 Homodimer activity in distal airway cells determines lung dysfunction in equine heaves. Vet. Immunol. Immunopathol. 2001; 80: 31526.
  • 80
    Bureau F, Delhalle S, Bonizzi G et al. Mechanisms of persistent NF-kappa B activity in the bronchi of an animal model of asthma. J. Immunol. 2000; 165: 582230.
  • 81
    Werners AH, Bull S, Vendrig JC et al. Genotyping of Toll-like receptor 4, myeloid differentiation factor 2 and CD-14 in the horse: an investigation into the influence of genetic polymorphisms on the LPS induced TNF-alpha response in equine whole blood. Vet. Immunol. Immunopathol. 2006; 111: 16573.
  • 82
    Pirie RS, McLachlan G, McGorum BC. Evaluation of nebulised hay dust suspensions (HDS) for the diagnosis and investigation of heaves. 1: preparation and composition of HDS. Equine Vet. J. 2002; 34: 3326.
  • 83
    Lavoie J-P. Recurrent airway obstruction (Heaves) and summer-pasture-associated obstructive pulmonary disease. In: McGorum BC, Dixon PM, Robinson NE et al. (eds) Equine Respiratory Medicine and Surgery. Saunders, Edinburgh, 2007; 56589.
  • 84
    Willoughby RA, McDonell WN. Pulmonary function testing in horses. Vet. Clin. North Am. Large Anim. Pract. 1979; 1: 17196.
  • 85
    Gillespie JR, Tyler WS, Eberly VE. Pulmonary ventilation and resistance in emphysematous and control horses. J. Appl. Physiol. 1966; 21: 41622.
  • 86
    Muylle E, Oyaert W. Lung function tests in obstructive pulmonary disease in horses. Equine Vet. J. 1973; 5: 3744.
  • 87
    Robinson NE, Derksen FJ, Olszewski MA et al. The pathogenesis of chronic obstructive pulmonary disease of horses. Br. Vet. J. 1996; 152: 283306.
  • 88
    Gallivan GJ, Viel L, McDonell WN. An evaluation of the multiple-breath nitrogen washout as a pulmonary function test in horses. Can. J. Vet. Res. 1990; 54: 99105.
  • 89
    Denac-Sikiric M. The functional residual capacity and helium mixing time in healthy horses and horses with lung diseases. Zentralbl. Veterinarmed. A. 1976; 23: 193205.
  • 90
    Rush BR, Hoskinson JJ, Davis EG et al. Pulmonary distribution of aerosolized technetium Tc 99m pentetate after administration of a single dose of aerosolized albuterol sulfate in horses with recurrent airway obstruction. Am. J. Vet. Res. 1999; 60: 7649.
  • 91
    Herholz CP, Gerber V, Tschudi P et al. Use of volumetric capnography to identify pulmonary dysfunction in horses with and without clinically apparent recurrent airway obstruction. Am. J. Vet. Res. 2003; 64: 33845.
  • 92
    Votion D, Ghafir Y, Vandenput S et al. Analysis of scintigraphical lung images before and after treatment of horses suffering from chronic pulmonary disease. Vet. Rec. 1999; 144: 2326.
  • 93
    Nyman G, Lindberg R, Weckner D et al. Pulmonary gas exchange correlated to clinical signs and lung pathology in horses with chronic bronchiolitis. Equine Vet. J. 1991; 23: 25360.
  • 94
    Robinson NE, Olszewski MA, Boehler D et al. Relationship between clinical signs and lung function in horses with recurrent airway obstruction (heaves) during a bronchodilator trial. Equine Vet. J. 2000; 32: 393400.
  • 95
    Robinson NE, Derksen FJ, Olszewski M et al. Determinants of the maximal change in pleural pressure during tidal breathing in COPD-affected horses. Vet. J. 1999; 157: 1605.
  • 96
    Petsche VM, Derksen FJ, Robinson NE. Tidal breathing flow-volume loops in horses with recurrent airway obstruction (heaves). Am. J. Vet. Res. 1994; 55: 88591.
  • 97
    Mazan MR, Deveney EF, DeWitt S et al. Energetic cost of breathing, body composition, and pulmonary function in horses with recurrent airway obstruction. J. Appl. Physiol. 2004; 97: 917.
  • 98
    Picandet V, Leguillette R, Lavoie JP. Comparison of efficacy and tolerability of isoflupredone and dexamethasone in the treatment of horses affected with recurrent airway obstruction (‘heaves’). Equine Vet. J. 2003; 35: 41924.
  • 99
    Young SS, Tesarowski D, Viel L. Frequency dependence of forced oscillatory respiratory mechanics in horses with heaves. J. Appl. Physiol. 1997; 82: 9837.
  • 100
    Mazan MR, Hoffman AM, Manjerovic N. Comparison of forced oscillation with the conventional method for histamine bronchoprovocation testing in horses. Am. J. Vet. Res. 1999; 60: 17480.
  • 101
    van Erck E, Votion DM, Kirschvink N et al. Use of the impulse oscillometry system for testing pulmonary function during methacholine bronchoprovocation in horses. Am. J. Vet. Res. 2003; 64: 141420.
  • 102
    Van Erck E, Votion D, Art T et al. Qualitative and quantitative evaluation of equine respiratory mechanics by impulse oscillometry. Equine Vet. J. 2006; 38: 528.
  • 103
    Richard EA, Fortier GD, Denoix JM et al. Influence of subclinical inflammatory airway disease on equine respiratory function evaluated by impulse oscillometry. Equine Vet. J. 2009; 41: 3849.
  • 104
    Beadle RE. Experiences with whole-body plethysmography in horses with obstructive pulmonary disease. Lung function and respiratory diseases in the horse International Symposium in Hannover, Germany, June. 1985.
  • 105
    Hoffman AM, Oura TJ, Riedelberger KJ et al. Plethysmographic comparison of breathing pattern in heaves (recurrent airway obstruction) versus experimental bronchoconstriction or hyperpnea in horses. J. Vet. Intern. Med. 2007; 21: 18492.
  • 106
    Couetil LL, Rosenthal FS, DeNicola DB et al. Clinical signs, evaluation of bronchoalveolar lavage fluid, and assessment of pulmonary function in horses with inflammatory respiratory disease. Am. J. Vet. Res. 2001; 62: 53846.
  • 107
    Couetil LL, Rosenthal FS, Simpson CM. Forced expiration: a test for airflow obstruction in horses. J. Appl. Physiol. 2000; 88: 18709.
  • 108
    Doucet MY, Vrins AA, Ford-Hutchinson AW. Histamine inhalation challenge in normal horses and in horses with small airway disease. Can. J. Vet. Res. 1991; 55: 28593.
  • 109
    Obel NJ, Schmiterlow CG. The action of histamine and other drugs on the bronchial tone in horses suffering from alveolar emphysema (heaves). Acta Pharmacol. Toxicol. (Copenh). 1948; 4: 7180.
  • 110
    Armstrong PJ, Derksen FJ, Slocombe RF et al. Airway responses to aerosolized methacholine and citric acid in ponies with recurrent airway obstruction (heaves). Am. Rev. Respir. Dis. 1986; 133: 35761.
  • 111
    Derksen FJ, Scott D, Robinson NE et al. Intravenous histamine administration in ponies with recurrent airway obstruction (heaves). Am. J. Vet. Res. 1985; 46: 7747.
  • 112
    Fairbairn SM, Lees P, Page CP et al. Duration of antigen-induced hyperresponsiveness in horses with allergic respiratory disease and possible links with early airway obstruction. J. Vet. Pharmacol. Ther. 1993; 16: 46976.
  • 113
    Derksen FJ, Robinson NE, Armstrong PJ et al. Airway reactivity in ponies with recurrent airway obstruction (heaves). J. Appl. Physiol. 1985; 58: 598604.
  • 114
    Votion DM, Vandenput SN, Duvivier DH et al. Alveolar clearance in horses with chronic obstructive pulmonary disease. Am. J. Vet. Res. 1999; 60: 495500.
  • 115
    Vandenput S, Votion D, Duvivier DH et al. Effect of a set stabled environmental control on pulmonary function and airway reactivity of COPD affected horses. Vet. J. 1998; 155: 18995.
  • 116
    Nuytten J, Deprez P, Picavet T et al. Comparison of different pulmonary function tests and their prognostic value in horses affected with COPD. Equine Vet. Sci. 1988; 8: 3614.
  • 117
    Viel L. Structural-functional correlations of the lung in horses with small airway disease (PhD Thesis). Guelph, ON, Canada: University of Guelph, 1983.
  • 118
    Johansson AM, Gardner SY, Atkins CE et al. Cardiovascular effects of acute pulmonary obstruction in horses with recurrent airway obstruction. J. Vet. Intern. Med. 2007; 21: 3027.
  • 119
    Larson VL, Busch RH. Equine tracheobronchial lavage: comparaison of lavage cytologic and pulmonary histopathologic findings. Am. J. Vet. Res. 1985; 46: 1446.
  • 120
    Derksen FJ, Brown CM, Sonea I et al. Comparaison of transtracheal aspirate and bronchoalveolar lavage cytology in 50 horses with chronic lung disease. Equine Vet. J. 1989; 21: 236.
  • 121
    Winder NC, Hermann M, Grünig G et al. Comparison of bronchoalveolar lavage and respiratory secretion cytology in horses with clinically diagnosed chronic pulmonary disease. Schweiz. Arch. Tierheilkd. 1990; 132: 50510.
  • 122
    Traub-Dargatz JL, McKinnon AO, Thrall MA et al. Evaluation of clinical signs of disease, bronchoalveolar and tracheal wash analysis, and arterial blood gas tensions in 13 horses with chronic obstructive pulmonary disease treated with prednisone, methyl sulfonmethane, and clenbuterol hydrochloride. Am. J. Vet. Res. 1992; 53: 190816.
  • 123
    Grootendorst DC, Sont JK, Willems LN et al. Comparison of inflammatory cell counts in asthma: induced sputum vs bronchoalveolar lavage and bronchial biopsies. Clin. Exp. Allergy 1997; 27: 76979.
  • 124
    Jean D, Vrins A, Beauchamp G et al. Evaluation variations in bronchoalveolar lavage fluid in horses with recurrent airway obstruction. Am. J. Vet. Res. 2011; 72: 83842.
  • 125
    Brazil TJ, Dagleish MP, McGorum BC et al. Kinetics of pulmonary neutrophil recruitment and clearance in a natural and spontaneously resolving model of airway inflammation. Clin. Exp. Allergy 2005; 35: 85465.
  • 126
    Fairbairn SM, Page CP, Lees P et al. Early neutrophil but not eosinophil or platelet recruitment to the lungs of allergic horses following antigen exposure. Clin. Exp. Allergy 1993; 23: 8218.
  • 127
    Marr KA, Lees P, Page CP et al. Effect of the 5-lipoxygenase inhibitor, fenleuton, on antigen-induced neutrophil accumulation and lung function changes in horses with chronic obstructive pulmonary disease. J. Vet. Pharmacol. Ther. 1998; 21: 2416.
  • 128
    Tremblay GM, Ferland C, Lapointe JM et al. Effect of stabling on bronchoalveolar cells obtained from normal and COPD horses. Equine Vet. J. 1993; 25: 1947.
  • 129
    Leclere M, Lavoie-Lamoureux A, Gelinas-Lymburner E et al. Effect of antigen exposure on airway smooth muscle remodeling in an equine model of chronic asthma. Am. J. Respir. Cell Mol. Biol. 2011; 45: 1817.
  • 130
    Lindberg A, Robinson NE, Nasman-Glaser B et al. Assessment of leukotriene B4 production in leukocytes from horses with recurrent airway obstruction. Am. J. Vet. Res. 2004; 65: 28995.
  • 131
    Nevalainen M, Raulo SM, Brazil TJ et al. Inhalation of organic dusts and lipopolysaccharide increases gelatinolytic matrix metalloproteinases (MMPs) in the lungs of heaves horses. Equine Vet. J. 2002; 34: 1505.
  • 132
    Franchini M, Gill U, von Fellenberg R et al. Interleukin-8 concentration and neutrophil chemotactic activity in bronchoalveolar lavage fluid of horses with chronic obstructive pulmonary disease following exposure to hay. Am. J. Vet. Res. 2000; 61: 136974.
  • 133
    Art T, Kirschvink N, Smith N et al. Indices of oxidative stress in blood and pulmonary epithelium lining fluid in horses suffering from recurrent airway obstruction. Equine Vet. J. 1999; 31: 397401.
  • 134
    Deaton CM, Marlin DJ, Smith NC et al. Breath condensate hydrogen peroxide correlates with both airway cytology and epithelial lining fluid ascorbic acid concentration in the horse. Free Radic. Res. 2004; 38: 2018.
  • 135
    Deaton CM, Marlin DJ, Smith NC et al. Pulmonary epithelial lining fluid and plasma ascorbic acid concentrations in horses affected by recurrent airway obstruction. Am. J. Vet. Res. 2004; 65: 807.
  • 136
    Lavoie-Lamoureux A, Moran K, Beauchamp G et al. IL-4 activates equine neutrophils and induces a mixed inflammatory cytokine expression profile with enhanced neutrophil chemotactic mediator release ex vivo. Am. J. Physiol. Lung Cell. Mol. Physiol. 2010; 299: L47282.
  • 137
    Huang H, Lavoie-Lamoureux A, Moran K et al. IL-4 stimulates the expression of CXCL-8, E-selectin, VEGF, and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 2007; 292: L114754.
  • 138
    Joubert P, Cordeau ME, Lavoie JP. Cytokine mRNA expression of pulmonary macrophages varies with challenge but not with disease state in horses with heaves or in controls. Vet. Immunol. Immunopathol. 2011; 142: 23642.
  • 139
    Laan TT, Bull S, Pirie RS et al. Evaluation of cytokine production by equine alveolar macrophages exposed to lipopolysaccharide, Aspergillus fumigatus, and a suspension of hay dust. Am. J. Vet. Res. 2005; 66: 15849.
  • 140
    Laan TT, Bull S, Pirie R et al. The role of alveolar macrophages in the pathogenesis of recurrent airway obstruction in horses. J. Vet. Intern. Med. 2006; 20: 16774.
  • 141
    Ainsworth DM, Wagner B, Erb HN et al. Effects of in vitro exposure to hay dust on expression of interleukin-17, -23, -8, and -1beta and chemokine (C-X-C motif) ligand 2 by pulmonary mononuclear cells isolated from horses chronically affected with recurrent airway disease. Am. J. Vet. Res. 2007; 68: 13619.
  • 142
    Ainsworth DM, Matychak M, Reyner CL et al. Effects of in vitro exposure to hay dust on the gene expression of chemokines and cell-surface receptors in primary bronchial epithelial cell cultures established from horses with chronic recurrent airway obstruction. Am. J. Vet. Res. 2009; 70: 36572.
  • 143
    Berndt A, Derksen FJ, Venta PJ et al. Elevated amount of Toll-like receptor 4 mRNA in bronchial epithelial cells is associated with airway inflammation in horses with recurrent airway obstruction. Am. J. Physiol. Lung Cell. Mol. Physiol. 2007; 292: L93643.
  • 144
    Jagels MA, Daffern PJ, Zuraw BL et al. Mechanisms and regulation of polymorphonuclear leukocyte and eosinophil adherence to human airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 1999; 21: 41827.
  • 145
    Marr KA, Foster AP, Lees P et al. Effect of antigen challenge on the activation of peripheral blood neutrophils from horses with chronic obstructive pulmonary disease. Res. Vet. Sci. 1997; 62: 25360.
  • 146
    Marr KA, Lees P, Cunningham FM. Antigen challenge increases adherence of circulating neutrophils in horses with chronic obstructive pulmonary disease. Equine Vet. J. 2002; 34: 6570.
  • 147
    Olszewski MA, Robinson NE, Zhu FX et al. Mediators of anaphylaxis but not activated neutrophils augment cholinergic responses of equine small airways. Am. J. Physiol. 1999; 276: L5229.
  • 148
    Rickards KJ, Page CP, Cunningham FM. Allergen challenge alters lymphocyte phosphodiesterase activity in horses with heaves. Pulm. Pharmacol. Ther. 2004; 17: 16372.
  • 149
    Ablett JM, Fairbairn SM, Page CP et al. Influence of antigen challenge on platelet responsiveness in horses with chronic obstructive pulmonary disease. Equine Vet. J. 1997; 29: 3826.
  • 150
    Costa LR, Eades SC, Venugopal CS et al. Plasma and pulmonary fluid endothelin in horses with seasonal recurrent airway obstruction. J. Vet. Intern. Med. 2009; 23: 123946.
  • 151
    Gray PR, Derksen FJ, Robinson NE et al. The role of cyclooxygenase products in the acute airway obstruction and airway hyperreactivity of ponies with heaves. Am. Rev. Respir. Dis. 1989; 140: 15460.
  • 152
    Kirschvink N, Smith N, Fievez L et al. Effect of chronic airway inflammation and exercise on pulmonary and systemic antioxidant status of healthy and heaves-affected horses. Equine Vet. J. 2002; 34: 56371.
  • 153
    Joubert P, Cordeau ME, Boyer A et al. Cytokine expression by peripheral blood neutrophils from heaves-affected horses before and after allergen challenge. Vet. J. 2008; 178: 22732.
  • 154
    Lavoie-Lamoureux A, Maghni K, Lavoie JP. Optimization of a procedure to accurately detect equine TNFalpha in serum samples. Vet. Immunol. Immunopathol. 2010; 138: 11823.
  • 155
    Cortes M-L. Évaluation de l'hémostase chez les chevaux atteints de pousse Créteil: Université de Créteil. 2008.
  • 156
    Lavoie-Lamoureux A, Leclere M, Lemos KR et al. Systemic inflammation is present in both remission and clinical exacerbation in an equine model of severe asthma. American Thoracic Society (ATS), Denver, CO, 2011.
  • 157
    Jousilahti P, Salomaa V, Hakala K et al. The association of sensitive systemic inflammation markers with bronchial asthma. Ann. Allergy Asthma Immunol. 2002; 89: 3815.
  • 158
    Higashimoto Y, Yamagata Y, Taya S et al. Systemic inflammation in chronic obstructive pulmonary disease and asthma: similarities and differences. Respirology 2008; 13: 12833.
  • 159
    Barnes PJ. Cytokine-directed therapies for the treatment of chronic airway diseases. Cytokine Growth Factor Rev. 2003; 14: 51122.
  • 160
    Koh YY, Kim YW, Park JD et al. A comparison of serum haptoglobin levels between acute exacerbation and clinical remission in asthma. Clin. Exp. Allergy 1996; 26: 12029.
  • 161
    Nadeem A, Chhabra SK, Masood A et al. Increased oxidative stress and altered levels of antioxidants in asthma. J. Allergy Clin. Immunol. 2003; 111: 728.
  • 162
    Wu TL, Chang PY, Tsao KC et al. A panel of multiple markers associated with chronic systemic inflammation and the risk of atherogenesis is detectable in asthma and chronic obstructive pulmonary disease. J. Clin. Lab. Anal. 2007; 21: 36771.
  • 163
    Kalhan R, Tran BT, Colangelo LA et al. Systemic inflammation in young adults is associated with abnormal lung function in middle age. PLoS ONE 2010; 5: e11431.
  • 164
    Kaup FJ, Drommer W, Damsch S et al. Ultrastructural findings in horses with chronic obstructive pulmonary disease (COPD). II: pathomorphological changes of the terminal airways and the alveolar region. Equine Vet. J. 1990; 22: 34955.
  • 165
    Dixon PM. Respiratory mucociliary clearance in the horse in health and disease, and its pharmaceutical modification. Vet. Rec. 1992; 131: 22935.
  • 166
    Gerber V, Straub R, Marti E et al. Endoscopic scoring of mucus quantity and quality: observer and horse variance and relationship to inflammation, mucus viscoelasticity and volume. Equine Vet. J. 2004; 36: 57682.
  • 167
    Robinson NE, Berney C, Eberhart S et al. Coughing, mucus accumulation, airway obstruction, and airway inflammation in control horses and horses affected with recurrent airway obstruction. Am. J. Vet. Res. 2003; 64: 5507.
  • 168
    Gerber V, Lindberg A, Berney C et al. Airway mucus in recurrent airway obstruction—short-term response to environmental challenge. J. Vet. Intern. Med. 2004; 18: 927.
  • 169
    Range F, Mundhenk L, Gruber AD. A soluble secreted glycoprotein (eCLCA1) is overexpressed due to goblet cell hyperplasia and metaplasia in horses with recurrent airway obstruction. Vet. Pathol. 2007; 44: 90111.
  • 170
    Costa LR, Seahorn TL, Moore RM et al. Correlation of clinical score, intrapleural pressure, cytologic findings of bronchoalveolar fluid, and histopathologic lesions of pulmonary tissue in horses with summer pasture-associated obstructive pulmonary disease. Am. J. Vet. Res. 2000; 61: 16773.
  • 171
    Jefcoat AM, Hotchkiss JA, Gerber V et al. Persistent mucin glycoprotein alterations in equine recurrent airway obstruction. Am. J. Physiol. Lung Cell. Mol. Physiol. 2001; 281: L70412.
  • 172
    Gerber V, King M, Schneider DA et al. Tracheobronchial mucus viscoelasticity during environmental challenge in horses with recurrent airway obstruction. Equine Vet. J. 2000; 32: 41117.
  • 173
    Shale DJ, Ionescu AA. Mucus hypersecretion: a common symptom, a common mechanism? Eur. Respir. J. 2004; 23: 7978.
  • 174
    Anton F, Leverkoehne I, Mundhenk L et al. Overexpression of eCLCA1 in small airways of horses with recurrent airway obstruction. J. Histochem. Cytochem. 2005; 53: 101121.
  • 175
    Gerber V, Robinson NE, Venta RJ et al. Mucin genes in horse airways: MUC5AC, but not MUC2, may play a role in recurrent airway obstruction. Equine Vet. J. 2003; 35: 2527.
  • 176
    Ryhner T, Muller N, Balmer V et al. Increased mucus accumulation in horses chronically affected with recurrent airway obstruction is not associated with up-regulation of CLCA1, EGFR, MUC5AC, Bcl-2, IL-13 and INF-gamma expression. Vet. Immunol. Immunopathol. 2008; 125: 817.
  • 177
    Gerber V, De Feijter-Rupp H, Wagner J et al. Differential association of MUC5AC and CLCA1 expression in small cartilaginous airways of RAO-affected and control horses. Equine Vet. J. 2009; 41: 81723.
  • 178
    Oslund KL, Adamson G, Wu R. Evaluation of MUC5AC expression and upregulation in airway epithelial cells of horses. Am. J. Vet. Res. 2010; 71: 6906.
  • 179
    Bartner LR, Robinson NE, Kiupel M et al. Persistent mucus accumulation: a consequence of delayed bronchial mucous cell apoptosis in RAO-affected horses? Am. J. Physiol. Lung Cell. Mol. Physiol. 2006; 291: L6029.
  • 180
    Abraham G, Kottke C, Ungemach FR. Equine recurrent airway obstruction does not alter airway muscarinic acetylcholine receptor expression and subtype distribution. J. Vet. Pharmacol. Ther. 2007; 30: 4019.
  • 181
    Broadstone RV, LeBlanc PH, Derksen FJ et al. In vitro responses of airway smooth muscle from horses with recurrent airway obstruction. Pulm. Pharmacol. 1991; 4: 191202.
  • 182
    LeBlanc PH, Broadstone RV, Derksen FJ et al. In vitro responses of distal airways in horses with recurrent airway obstruction. Am. J. Vet. Res. 1991; 52: 9991003.
  • 183
    Yu MF, Wang ZW, Robinson NE et al. Modulation of bronchial smooth muscle function in horses with heaves. J. Appl. Physiol. 1994; 77: 214954.
  • 184
    Coulson FR, Fryer AD. Muscarinic acetylcholine receptors and airway diseases. Pharmacol. Ther. 2003; 98: 5969.
  • 185
    Fryer AD, Jacoby DB. Muscarinic receptors and control of airway smooth muscle. Am. J. Respir. Crit. Care Med. 1998; 158: S15460.
  • 186
    Zhang XY, Robinson NE, Zhu FX. Modulation of ACh release from airway cholinergic nerves in horses with recurrent airway obstruction. Am. J. Physiol. 1999; 276: L76975.
  • 187
    Abraham G, Kottke C, Dhein S et al. Agonist-independent alteration in beta-adrenoceptor-G-protein-adenylate cyclase system in an equine model of recurrent airway obstruction. Pulm. Pharmacol. Ther. 2006; 19: 21829.
  • 188
    Venugopal CS, Holmes EP, Polikepahad S et al. Neurokinin receptors in recurrent airway obstruction: a comparative study of affected and unaffected horses. Can. J. Vet. Res. 2009; 73: 2533.
  • 189
    Rosas-Ballina M, Tracey KJ. Cholinergic control of inflammation. J. Intern. Med. 2009; 265: 66379.
  • 190
    Huang H, Lavoie-Lamoureux A, Lavoie JP. Cholinergic stimulation attenuates the IL-4 induced expression of E-selectin and vascular endothelial growth factor by equine pulmonary artery endothelial cells. Vet. Immunol. Immunopathol. 2009; 132: 11621.
  • 191
    Lavoie JP, Leguillette R, Pasloske K et al. Comparison of effects of dexamethasone and the leukotriene D4 receptor antagonist L-708,738 on lung function and airway cytologic findings in horses with recurrent airway obstruction. Am. J. Vet. Res. 2002; 63: 57985.
  • 192
    Thurlbeck WM, Lowell FC. Heaves in horses. Am. J. Respir. Dis. 1964; 89: 828.
  • 193
    Winder NC, von Fellenberg R. Chronic small airway disease in horses slaughtered in Switzerland. Schweiz. Arch. Tierheilkd. 1987; 129: 58593.
  • 194
    Katavolos P, Ackerley CA, Viel L et al. Clara cell secretory protein is reduced in equine recurrent airway obstruction. Vet. Pathol. 2009; 46: 60413.
  • 195
    Gerber H. Chronic pulmonary disease in the horse. Equine Vet. J. 1973; 5: 2633.
  • 196
    Naylor JM, Clark EG, Clayton HM. Chronic obstructive pulmonary disease: usefulness of clinical signs, bronchoalveolar lavage, and lung biopsy as diagnostic and prognostic aids. Can. Vet. J. 1992; 33: 5918.
  • 197
    Kaup FJ, Drommer W, Deegen E. Ultrastructural findings in horses with chronic obstructive pulmonary disease (COPD). I: alterations of the larger conducting airways. Equine Vet. J. 1990; 22: 3438.
  • 198
    Lugo J, Harkema JR, deFeijter-Rupp H et al. Airway inflammation is associated with mucous cell metaplasia and increased intraepithelial stored mucosubstances in horses. Vet. J. 2006; 172: 293301.
  • 199
    Herszberg B, Ramos-Barbon D, Tamaoka M et al. Heaves, an asthma-like equine disease, involves airway smooth muscle remodeling. J. Allergy Clin. Immunol. 2006; 118: 3828.
  • 200
    Leclere M, Lavoie-Lamoureux A, Martin J et al. Inhaled corticosteroids accelerate the reversal of airway smooth muscle remodeling in an equine model of chronic asthma. American Thoracic Society International Conference, New Orleans, 2010; A2302.
  • 201
    McPherson EA, Lawson GH. Some aspects of chronic pulmonary diseases of horses and methods used in their investigation. Equine Vet. J. 1974; 6: 16.
  • 202
    Cook WR. Chronic bronchitis and alveolar emphysema in the horse. Vet. Rec. 1976; 99: 44851.
  • 203
    Lanctot-Setlakwe E, Leclère M, Lavoie J. Sub-Epithelial Fibrosis is Present in the Peripheral Airways of Heaves-Afftected Horses, an Equine Model for Asthma. American Thoracic Society (ATS), San Diego, CA, 2009.
  • 204
    Furness MC, Bienzle D, Caswell JL et al. Immunohistochemical identification of collagen in the equine lung. Vet. Pathol. 2010; 47: 98290.
  • 205
    National Heart, Lung, and Blood Institute. National Asthma Education and Prevention Program Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. National Institutes of Health, Bethesda, MD, 2007.
  • 206
    Couetil LL, Chilcoat CD, DeNicola DB et al. Randomized, controlled study of inhaled fluticasone propionate, oral administration of prednisone, and environmental management of horses with recurrent airway obstruction. Am. J. Vet. Res. 2005; 66: 166574.
  • 207
    Dixon PM, Railton DI, McGorum BC et al. Equine pulmonary disease: a case control study of 300 referred cases. Part 4: treatments and re-examination findings. Equine Vet. J. 1995; 27: 4369.
  • 208
    DeLuca L, Erb HN, Young JC et al. The effect of adding oral dexamethasone to feed alterations on the airway cell inflammatory gene expression in stabled horses affected with recurrent airway obstruction. J. Vet. Intern. Med. 2008; 22: 42735.
  • 209
    Thomson JR, McPherson EA. Effects of environmental control on pulmonary function of horses affected with chronic obstructive pulmonary disease. Equine Vet. J. 1984; 16: 358.
  • 210
    Beadle RE. Summer pasture-associated obstructive pulmonary disease. In: Robinson NE (ed.) Current Therapy in Equine Medicine. WB Saunders Co, Philadelphia, PA, 1983; 51216.
  • 211
    Gerber V, Schott Ii HC, Robinson NE. Owner assessment in judging the efficacy of airway disease treatment. Equine Vet. J. 2011; 43: 1538.
  • 212
    Williamson KK, Davis MS. Evidence-based respiratory medicine in horses. Vet. Clin. North Am. Equine Pract. 2007; 23: 21527.
  • 213
    Cornelisse CJ, Robinson NE, Berney CE et al. Efficacy of oral and intravenous dexamethasone in horses with recurrent airway obstruction. Equine Vet. J. 2004; 36: 42630.
  • 214
    Leclere M, Lefebvre-Lavoie J, Beauchamp G et al. Efficacy of oral prednisolone and dexamethasone in horses with recurrent airway obstruction in the presence of continuous antigen exposure. Equine Vet. J. 2010; 42: 31621.
  • 215
    Rush BR, Raub ES, Rhoads WS et al. Pulmonary function in horses with recurrent airway obstruction after aerosol and parenteral administration of beclomethasone dipropionate and dexamethasone, respectively. Am. J. Vet. Res. 1998; 59: 103943.
  • 216
    Rush BR, Flaminio MJ, Matson CJ et al. Cytologic evaluation of bronchoalveolar lavage fluid from horses with recurrent airway obstruction after aerosol and parenteral administration of beclomethasone dipropionate and dexamethasone, respectively. Am. J. Vet. Res. 1998; 59: 10338.
  • 217
    Lavoie JP, Pasloske K, Joubert P et al. Lack of clinical efficacy of a phosphodiesterase-4 inhibitor for treatment of heaves in horses. J. Vet. Intern. Med. 2006; 20: 17581.
  • 218
    Couetil LL, Art T, de Moffarts B et al. Effect of beclomethasone dipropionate and dexamethasone isonicotinate on lung function, bronchoalveolar lavage fluid cytology, and transcription factor expression in airways of horses with recurrent airway obstruction. J. Vet. Intern. Med. 2006; 20: 399406.
  • 219
    Lecoq L, Vincent P, Lavoie-Lamoureux A et al. Genomic and non-genomic effects of dexamethasone on equine peripheral blood neutrophils. Vet. Immunol. Immunopathol. 2009; 128: 12631.
  • 220
    Lakser OJ, Dowell ML, Hoyte FL et al. Steroids augment relengthening of contracted airway smooth muscle: potential additional mechanism of benefit in asthma. Eur. Respir. J. 2008; 32: 122430.
  • 221
    Dauvillier J, Felippe MJ, Lunn DP et al. Effect of long-term fluticasone treatment on immune function in horses with heaves. J. Vet. Intern. Med. 2011; 25: 54957.
  • 222
    Burguez PN, Ousey J, Cash RS et al. Changes in blood neutrophil and lymphocyte counts following administration of cortisol to horses and foals. Equine Vet. J. 1983; 15: 5860.
  • 223
    Targowski SP. Effect of prednisolone on the leukocyte counts of ponies and on the reactivity of lymphocytes in vitro and in vivo. Infect. Immun. 1975; 11: 2526.
  • 224
    Flaminio MJBF, Tallmadge RL, Secor E et al. The effect of glucocorticoid therapy in the immune system of the horse. Proceedings and abstracts of the 8th International Veterinary Immunology Symposium, August 15–19, 2007, Ouro Preto, Brazil. Vet. Immunol. Immunopathol. 2009; 128: 1347.
  • 225
    Slack J, Risdahl JM, Valberg SJ et al. Effects of dexamethasone on development of immunoglobulin G subclass responses following vaccination of horses. Am. J. Vet. Res. 2000; 61: 15303.
  • 226
    Bertin FR, Ivester KM, Couetil LL. Comparative efficacy of inhaled albuterol between two hand-held delivery devices in horses with recurrent airway obstruction. Equine Vet. J. 2011; 43: 3938.
  • 227
    Camargo FC, Robinson NE, Berney C et al. Trimetoquinol: bronchodilator effects in horses with heaves following aerosolised and oral administration. Equine Vet. J. 2007; 39: 21520.
  • 228
    Matera MG, Calzetta L, Rogliani P et al. Evaluation of the effects of the R- and S-enantiomers of salbutamol on equine isolated bronchi. Pulm. Pharmacol. Ther. 2011; 24: 2216.
  • 229
    Perrin-Fayolle M, Blum PS, Morley J et al. Differential responses of asthmatic airways to enantiomers of albuterol. Implications for clinical treatment of asthma. Clin. Rev. Allergy Immunol. 1996; 14: 13947.
  • 230
    Wilkinson M, Bulloch B, Garcia-Filion P et al. Efficacy of racemic albuterol versus levalbuterol used as a continuous nebulization for the treatment of acute asthma exacerbations: a randomized, double-blind, clinical trial. J. Asthma 2011; 48: 18893.
  • 231
    Erichsen DF, Aviad AD, Schultz RH et al. Clinical efficacy and safety of clenbuterol HCl when administered to effect in horses with chronic obstructive pulmonary disease (COPD). Equine Vet. J. 1994; 26: 3316.
  • 232
    Derksen FJ, Scott JS, Slocombe RF et al. Effect of clenbuterol on histamine-induced airway obstruction in ponies. Am. J. Vet. Res. 1987; 48: 4236.
  • 233
    Kiely RG, Jenkins WL. The effect of clenbuterol chloride on the mucociliary transport rate in horses with a clinical diagnosis of chronic obstructive pulmonary disease (COPD). Proceedings of the American College of Veterinary Internal Medicine, San Diego, Calif, USA, 1985; 146.
  • 234
    Laan TT, Bull S, Pirie RS et al. The anti-inflammatory effects of IV administered clenbuterol in horses with recurrent airway obstruction. Vet. J. 2006; 171: 42937.
  • 235
    van den Hoven R, Duvigneau JC, Hartl RT et al. Clenbuterol affects the expression of messenger RNA for interleukin 10 in peripheral leukocytes from horses challenged intrabronchially with lipopolysaccharides. Vet. Res. Commun. 2006; 30: 9218.
  • 236
    Abraham G, Brodde OE, Ungemach FR. Regulation of equine lymphocyte beta-adrenoceptors under the influence of clenbuterol and dexamethasone. Equine Vet. J. 2002; 34: 58793.
  • 237
    Duvivier DH, Bayly WM, Votion D et al. Effects of inhaled dry powder ipratropium bromide on recovery from exercise of horses with COPD. Equine Vet. J. 1999; 31: 204.
  • 238
    Ducharme NG, Fubini SL. Gastrointestinal complications associated with the use of atropine in horses. J. Am. Vet. Med. Assoc. 1983; 182: 22931.
  • 239
    Pearson EG, Riebold TW. Comparison of bronchodilators in alleviating clinical signs in horses with chronic obstructive pulmonary disease. J. Am. Vet. Med. Assoc. 1989; 194: 128791.
  • 240
    McKiernan BC, Koritz GD. Plasma theophylline concentration and lung function in ponies with recurrent obstructive lung disease. Equine Vet. J. 1990; 22: 1947.
  • 241
    Cesarini C, Hamilton E, Picandet V et al. Theophylline does not potentiate the effects of a low dose of dexamethasone in horses with recurrent airway obstruction. Equine Vet. J. 2006; 38: 5703.
  • 242
    Leguillette R, Desevaux C, Lavoie JP. Effects of pentoxifylline on pulmonary function and results of cytologic examination of bronchoalveolar lavage fluid in horses with recurrent airway obstruction. Am. J. Vet. Res. 2002; 63: 45963.
  • 243
    Thomson JR, McPherson EA. Chronic obstructive pulmonary disease in the horse. 2: therapy. Equine Vet. J. 1983; 15: 20710.
  • 244
    Barnes PJ. Theophylline: new perspectives for an old drug. Am. J. Respir. Crit. Care Med. 2003; 167: 81318.
  • 245
    Barton AK, Niedorf F, Gruber AD et al. Pharmacological studies of bronchial constriction inhibited by parasympatholytics and cilomilast using equine precision-cut lung slices. Berl. Munch. Tierarztl. Wochenschr. 2010; 123: 22935.
  • 246
    Olszewski MA, Zhang XY, Robinson NE. Pre- and postjunctional effects of inflammatory mediators in horse airways. Am. J. Physiol. 1999; 277: L327L33.
  • 247
    Marr KA, Lees P, Page CP et al. Inhaled leukotrienes cause bronchoconstriction and neutrophil accumulation in horses. Res. Vet. Sci. 1998; 64: 21924.
  • 248
    Robinson NE, Boehler D, Berney C et al. Failure of a FLAP antagonist to prevent airway obstruction in heaves-suceptible horses. World Equine Airway Symposium, Guelph, Ontario, Canada, 1998; 31.
  • 249
    Kolm G, Zappe H, Schmid R et al. Efficacy of montelukast in the treatment of chronic obstructive pulmonary disease in five horses. Vet. Rec. 2003; 152: 8046.
  • 250
    Thomson JR, McPherson EA. Prophylactic effects of sodium cromoglycate on chronic obstructive pulmonary disease in the horse. Equine Vet. J. 1981; 13: 2436.
  • 251
    Soma LR, Beech J, Gerber NH. Effects of cromolyn in horses with chronic obstructive pulmonary disease. Vet. Sci. Commun. 1987; 11: 33951.
  • 252
    Lavoie JP, Thompson D, Hamilton E et al. Effects of a MAPK p38 inhibitor on lung function and airway inflammation in equine recurrent airway obstruction. Equine Vet. J. 2008; 40: 57783.
  • 253
    Eckert RE, Sharief Y, Jones SL. p38 mitogen-activated kinase (MAPK) is essential for equine neutrophil migration. Vet. Immunol. Immunopathol. 2009; 129: 18191.
  • 254
    Reinero CR. Advances in the understanding of pathogenesis, and diagnostics and therapeutics for feline allergic asthma. Vet. J. 2010; doi: S1090-0233(10)00313-8 [pii] 10.1016/j.tvjl.2010.09.022.
  • 255
    Leemans J, Kirschvink N, Clercx C et al. Effect of short-term oral and inhaled corticosteroids on airway inflammation and responsiveness in a feline acute asthma model. Vet. J. 2011; doi: S1090-0233(11)00039-6 [pii] 10.1016/j.tvjl.2011.01.020 (Epub ahead of print).
  • 256
    Kirschvink N, Reinhold P. Use of alternative animals as asthma models. Curr. Drug Targets 2008; 9: 47084.
  • 257
    Bice DE, Seagrave J, Green FH. Animal models of asthma: potential usefulness for studying health effects of inhaled particles. Inhal. Toxicol. 2000; 12: 82962.
  • 258
    McLaughlin RF Jr. Bronchial artery distribution in various mammals and in humans. Am. Rev. Respir. Dis. 1983; 128: S578.
  • 259
    Magno M. Comparative anatomy of the tracheobronchial circulation. Eur. Respir. J. Suppl. 1990; 12: 557s62s. Discussion 62s–63s.
  • 260
    McLaughlin RF, Tyler WS, Canada RO. Subgross pulmonary anatomy in various mammals and man. JAMA 1961; 175: 6947.
  • 261
    Robinson NE. How horses breathe: the respiratory muscles and the airways. In: McGorum BC, Dixon PM, Robinson NE et al. (eds) Equine Respiratory Medicine and Surgery. Saunders Elsevier, Philadelphia, PA, 2007; 1931.
  • 262
    Miller HR, Pemberton AD. Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut. Immunology 2002; 105: 37590.
  • 263
    Derksen FJ, Olszewski M, Robinson NE et al. Use of a hand-held, metered-dose aerosol delivery device to administer pirbuterol acetate to horses with ‘heaves’. Equine Vet. J. 1996; 28: 30610.
  • 264
    Jean D, Vrins A, Lavoie JP. Monthly, daily, and circadian variations of measurements of pulmonary mechanics in horses with chronic obstructive pulmonary disease. Am. J. Vet. Res. 1999; 60: 13416.
  • 265
    Ammann VJ, Vrins AA, Lavoie JP. Effects of inhaled beclomethasone dipropionate on respiratory function in horses with chronic obstructive pulmonary disease (COPD). Equine Vet. J. 1998; 30: 1527.
  • 266
    Relave F, David F, Leclere M et al. Evaluation of a thoracoscopic technique using ligating loops to obtain large lung biopsies in standing healthy and heaves-affected horses. Vet. Surg. 2008; 37: 23240.
  • 267
    Relave F, David F, Leclere M et al. Thoracoscopic lung biopsies in heaves-affected horses using a bipolar tissue sealing system. Vet. Surg. 2010; 39: 83946.
  • 268
    Lugo J, Stick JA, Peroni J et al. Safety and efficacy of a technique for thoracoscopically guided pulmonary wedge resection in horses. Am. J. Vet. Res. 2002; 63: 123240.
  • 269
    Laumen E, Doherr MG, Gerber V. Relationship of horse owner assessed respiratory signs index to characteristics of recurrent airway obstruction in two Warmblood families. Equine Vet. J. 2010; 42: 1428.
  • 270
    Wasko AJ, Barkema HW, Nicol J et al. Evaluation of a risk-screening questionnaire to detect equine lung inflammation: results of a large field study. Equine Vet. J. 2011; 43: 14552.
  • 271
    Martin RJ, Cicutto LC, Smith HR et al. Airways inflammation in nocturnal asthma. Am. Rev. Respir. Dis. 1991; 143: 3517.
  • 272
    Metzger WJ, Zavala D, Richerson HB et al. Local allergen challenge and bronchoalveolar lavage of allergic asthmatic lungs. Description of the model and local airway inflammation. Am. Rev. Respir. Dis. 1987; 135: 43340.
  • 273
    Amin K, Ludviksdottir D, Janson C et al. Inflammation and structural changes in the airways of patients with atopic and nonatopic asthma. BHR Group. Am. J. Respir. Crit. Care Med. 2000; 162: 2295301.
  • 274
    Asman B, Strand V, Bylin G et al. Peripheral neutrophils after allergic asthmatic reactions. Int. J. Clin. Lab. Res. 1997; 27: 1858.
  • 275
    Sur S, Crotty TB, Kephart GM et al. Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa? Am. Rev. Respir. Dis. 1993; 148: 71319.
  • 276
    Lamblin C, Gosset P, Tillie-Leblond I et al. Bronchial neutrophilia in patients with noninfectious status asthmaticus. Am. J. Respir. Crit. Care Med. 1998; 157: 394402.
  • 277
    Norzila MZ, Fakes K, Henry RL et al. Interleukin-8 secretion and neutrophil recruitment accompanies induced sputum eosinophil activation in children with acute asthma. Am. J. Respir. Crit. Care Med. 2000; 161: 76974.
  • 278
    Turner MO, Hussack P, Sears MR et al. Exacerbations of asthma without sputum eosinophilia. Thorax 1995; 50: 105761.
  • 279
    Fahy JV, Kim KW, Liu J et al. Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation. J. Allergy Clin. Immunol. 1995; 95: 84352.
  • 280
    Abdulamir AS, Hafidh RR, Abubakar F et al. Changing survival, memory cell compartment, and T-helper balance of lymphocytes between severe and mild asthma. BMC Immunol. 2008; 9: 73.
  • 281
    Quintana AM, Landolt GA, Annis KM et al. Immunological characterization of the equine airway epithelium and of a primary equine airway epithelial cell culture model. Vet. Immunol. Immunopathol. 2011; 140: 22636.
  • 282
    Gerber V, Baleri D, Klukowska-Rotzler J et al. Mixed inheritance of equine recurrent airway obstruction. J. Vet. Intern. Med. 2009; 23: 62630.
  • 283
    Klukowska-Rotzler J, Marti E, Bugno M et al. Molecular cloning and characterization of equine thymic stromal lymphopoietin. Vet. Immunol. Immunopathol. 2010; 136: 3469.
  • 284
    Wagner B, Hillegas JM, Brinker DR et al. Characterization of monoclonal antibodies to equine interleukin-10 and detection of T regulatory 1 cells in horses. Vet. Immunol. Immunopathol. 2008; 122: 5764.
  • 285
    Mauel S, Steinbach F, Ludwig H. Monocyte-derived dendritic cells from horses differ from dendritic cells of humans and mice. Immunology 2006; 117: 46373.
  • 286
    Flaminio MJ, Borges AS, Nydam DV et al. The effect of CpG-ODN on antigen presenting cells of the foal. J. Immune Based Ther. Vaccines 2007; 5: 1.
  • 287
    Couetil LL, Art T, de Moffarts B et al. DNA binding activity of transcription factors in bronchial cells of horses with recurrent airway obstruction. Vet. Immunol. Immunopathol. 2006; 113: 1120.
  • 288
    Christmann U, Hite RD, Tan RH et al. Surfactant alterations in horses with recurrent airway obstruction at various clinical stages. Am. J. Vet. Res. 2010; 71: 46875.
  • 289
    Brooks AC, Rickards KJ, Cunningham FM. CXCL8 attenuates chemoattractant-induced equine neutrophil migration. Vet. Immunol. Immunopathol. 2011; 139: 1417.
  • 290
    Hirsch G, Lavoie-Lamoureux A, Lavoie J-P. Comparison of blood neutrophils and mononuclear cells steroid responsiveness. American Thoracic Society International Conference, Denver, CO, 2011.