Reference values for airway resistance in newborns, infants and preschoolers from a Latin American population
Article first published online: 19 APR 2012
© 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology
Volume 17, Issue 4, pages 667–673, May 2012
How to Cite
GOCHICOA, L. G., THOMÉ-ORTIZ, L. P., FURUYA, M. E. Y., CANTO, R., RUIZ-GARCÍA, M. E., ZÚÑIGA-VÁZQUEZ, G., MARTÍNEZ-RAMÍREZ, F. and VARGAS, M. H. (2012), Reference values for airway resistance in newborns, infants and preschoolers from a Latin American population. Respirology, 17: 667–673. doi: 10.1111/j.1440-1843.2012.02156.x
- Issue published online: 19 APR 2012
- Article first published online: 19 APR 2012
- Accepted manuscript online: 28 FEB 2012 07:59AM EST
- Received 1 August 2011; invited to revise 11 September 2011, 29 November 2011, 3 December 2011; revised 2 November 2011, 2 December 2011, 6 December 2011; accepted 6 December 2011 (Associate Editor: Chi Chiu Leung).
- lung function;
- predicted value;
- pulmonary function test;
- Rint technique
Background and objective: Several studies have determined reference values for airway resistance measured by the interrupter technique (Rint) in paediatric populations, but only one has been done on Latin American children, and no studies have been performed on Mexican children. Moreover, these previous studies mostly included children aged 3 years and older; therefore, information regarding Rint reference values for newborns and infants is scarce.
Methods: Rint measurements were performed on preschool children attending eight kindergartens (Group 1) and also on sedated newborns, infants and preschool children admitted to a tertiary-level paediatric hospital due to non-cardiopulmonary disorders (Group 2).
Results: In both groups, Rint values were inversely associated with age, weight and height, but the strongest association was with height. The linear regression equation for Group 1 (n = 209, height 86–129 cm) was Rint = 2.153 − 0.012 × height (cm) (standard deviation of residuals 0.181 kPa/L/s). The linear regression equation for Group 2 (n = 55, height 52–113 cm) was Rint = 4.575 − 0.035 × height (cm) (standard deviation of residuals 0.567 kPa/L/s). Girls tended to have slightly higher Rint values than boys, a difference that diminished with increasing height.
Conclusions: In this study, Rint reference values applicable to Mexican children were determined, and these values are probably also applicable to other paediatric populations with similar Spanish-Amerindian ancestries. There was an inverse relationship between Rint and height, with relatively large between-subject variability.