The Authors: Dr Kendall is an expert environmental scientist, with 12 years of international faculty-level experience who specializes in exposure measurement, nano-characterization and health-impact assessment of fine particulate matter and nanoparticles. She was awarded the prestigious Rosenblith Prize by the Health Effects Institute in 2004. Professor Stephen T. Holgate is an MRC Clinical Professor in Immunopharmacology with research interests in the mechanisms of asthma and its treatment. He has published over 980 peer reviewed papers and is co-editor of key textbooks. He is past Chair and now member of the UK Department of Health's Committee on Medical Effects of Air Pollutants.
INVITED REVIEW SERIES: AIR POLLUTION AND LUNG HEALTH†
Health impact and toxicological effects of nanomaterials in the lung
Article first published online: 25 JUN 2012
© 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology
Volume 17, Issue 5, pages 743–758, July 2012
How to Cite
KENDALL, M. and HOLGATE, S. (2012), Health impact and toxicological effects of nanomaterials in the lung. Respirology, 17: 743–758. doi: 10.1111/j.1440-1843.2012.02171.x
SERIES EDITORS: IAN YANG AND STEPHEN HOLGATE
- Issue published online: 25 JUN 2012
- Article first published online: 25 JUN 2012
- Accepted manuscript online: 26 MAR 2012 05:23PM EST
- Received 29 November 2011; invited to revise 20 December 2011; revised 15 February 2012; accepted 17 February 2012.
Vol. 17, Issue 6, 1027, Article first published online: 29 JUL 2012
- engineered nanoparticle (ENP);
- mechanisms of toxicity;
- nanoparticle (NP);
The manufacture, use and disposal of nanomaterials will result in increased human exposures to engineered nanoparticles (ENPs), potentially via the lung. ENPs differ physically and chemically from natural- or combustion-derived nanoparticles (NP) in important respects. While there are parallels with ultrafine aerosol particles in the atmosphere and colloids in water, there remain some unique issues and impacts of engineered materials on lung health that require consideration and urgent study.
The study of toxicity of nanomaterials in biological systems—nanotoxicology—emerged from the observed effects of inhaled particulate matter (PM) and NP. Some engineered nanomaterials deserve special toxicological examination because of their unique properties in biological systems; novel toxicological approaches may be required for their assessment. Translocation in biological systems—a key feature of ENPs—is dependent on ENP size and surface interactions with macromolecules at the portal of entry, upstream of cellular interaction. Of particular significance is the agglomeration processes associated with macromolecule adsorption at ENP surfaces, which determine clearance rates and cellular response. ENP toxicity is therefore dominated by three linked physico-chemical factors: size-shape, surface and ‘corona’ (formed by adhering macromolecules from the suscipient host). Measuring and predicting ENP translocation and effects following lung entry have proven to be particularly challenging, but understanding ENP behaviour in vivo is fundamental for safe design for effective and targeted drug delivery. Human exposures via medical and dental applications appear important in terms of dose and toxicity, and may need to be assessed for risk on a case-by-case basis.