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ORIGINAL ARTICLE
Association between the CD209 promoter −336A/G polymorphism and susceptibility to tuberculosis: A meta-analysis
Article first published online: 25 JUN 2012
DOI: 10.1111/j.1440-1843.2012.02185.x
© 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology
Additional Information
How to Cite
MIAO, R., LI, J., SUN, Z., LI, C. and XU, F. (2012), Association between the CD209 promoter −336A/G polymorphism and susceptibility to tuberculosis: A meta-analysis. Respirology, 17: 847–853. doi: 10.1111/j.1440-1843.2012.02185.x
Publication History
- Issue published online: 25 JUN 2012
- Article first published online: 25 JUN 2012
- Accepted manuscript online: 3 MAY 2012 10:33PM EST
- Received 24 October 2011; invited to revise 9 January 2012; revised 26 January 2012; accepted 16 February 2012 (Associate Editor: Robert Young)
Keywords:
- CD209;
- meta-analysis;
- polymorphism;
- susceptibility;
- tuberculosis
ABSTRACT
Background and objective: Dendritic cell-specific intracellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN), encoded by the CD209 gene, is a major Mycobacterium tuberculosis receptor on human dendritic cells. The potentially functional −336A/G polymorphism in the CD209 promoter region has been associated with susceptibility to tuberculosis (TB), but the results have been inconclusive. We performed a meta-analysis to clarify the relationship between the CD209−336A/G variant and the risk of TB.
Methods: Ten studies involving a total of 2598 TB patients and 2614 control subjects were systematically reviewed, and the data were quantitatively synthesized by meta-analysis. The Q-test was applied to assess the heterogeneity of associations among the studies, and Egger's regression test was used to assess potential publication bias.
Results: No significant association was identified between the CD209−336A/G polymorphism and risk of TB (G allele vs A allele: odds ratio (OR) 1.02, 95% confidence interval (CI) 0.90–1.15). Moreover, no significant association was observed in populations of African ethnicity (OR 1.01, 95% CI 0.87–1.17) or among individuals who were negative for the human immunodeficiency virus (OR 0.98, 95% CI 0.84–1.15).
Conclusions: This meta-analysis has indicated that the CD209−336A/G polymorphism may not contribute to susceptibility to TB.