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Keywords:

  • Early infantile autism;
  • Minor physical anomaly;
  • Fragile X syndrome;
  • Embryonic period.

Abstract

The incidence of 28 minor physical anomalies was examined in 118 patients with early infantile autism, 132 patients with 21 trisomy, and 237 normal subjects.

Although the incidence of minor physical anomalies in children with early infantile autism was slightly higher than in the group of normal subjects, there was no significant difference between the groups. It was suggested from these findings that there is little possibility of the onset of early infantile autism being due to environmental insults at the embryonic period when minor physical anomalies are formed, and that there is no possibility of minor physical anomalies giving a clue as to the time of onset of early infantile autism. The incidence of minor physical anomalies in patients with 21 trisomy was significantly higher than in the group of normal subjects and of children with early infantile autism (p < 0.00l).

Fra (X) was noted in two patients among 40 examined. These patients were not included among the subjects in the present study.