Umbilical serum concentrations of chemokines (RANTES and MGSA/GRO-α) in preterm and term neonates
Version of Record online: 22 NOV 2006
Volume 48, Issue 6, pages 586–590, December 2006
How to Cite
KRÓLAK-OLEJNIK, B., BECK, B. and OLEJNIK, I. (2006), Umbilical serum concentrations of chemokines (RANTES and MGSA/GRO-α) in preterm and term neonates. Pediatrics International, 48: 586–590. doi: 10.1111/j.1442-200X.2006.02289.x
- Issue online: 22 NOV 2006
- Version of Record online: 22 NOV 2006
- Received 22 December 2004; revised 21 September 2005; accepted 27 September 2005.
Background: The objective of this study was to explore the relationship between labor (preterm and term) and umbilical blood serum regulated on activation, normal T cell expressed and secreted (RANTES) and melanoma growth stimulatory activity/growth-related oncogene-a (MSGA/GRO-α) concentration, and to determine whether early sepsis and pneumonia are associated with changes in concentrations of the chemokines (RANTES and MSGA/GRO-α) in umbilical blood serum.
Methods: Umbilical blood was obtained from 67 neonates in the following groups: (i) preterm neonates with early sepsis; (ii) preterm neonates with pneumonia; (iii) non-infected preterm neonates; and (iv) full-term healthy neonates. RANTES and MGSA/GRO-α concentrations were determined by use of a commercially available immunoassay kit.
Results: Non-infected preterm neonates had lower RANTES concentrations than healthy term neonates. Preterm infected neonates (pneumonia or sepsis) did not have higher RANTES concentrations than non-infected preterm neonates. In contrast, non-infected preterm neonates had higher MSGA/GRO-α concentrations than full-term healthy neonates. And preterm neonates with sepsis had higher MGSA/GRO-α concentrations than preterm ones with pneumonia and non-infected preterm ones.
Conclusions: Preterm neonates had constitutively lower RANTES concentrations than term ones and it seems that during infection RANTES concentrations did not increase. MGSA/GRO-a concentrations were constitutively higher in preterm than term neonates, and septic events further increased its concentrations in preterm neonates.