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Umbilical serum concentrations of chemokines (RANTES and MGSA/GRO-α) in preterm and term neonates

Authors

  • BARBARA KRÓLAK-OLEJNIK,

    Corresponding author
    1. Departments of1Perinatology and Gynecology and 2Biochemistry, Medical University of Silesia, Zabrze and 3Center of Pediatrics and Oncology, Chorzow, Poland
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  • 1 BRYGIDA BECK,

    1. Departments of1Perinatology and Gynecology and 2Biochemistry, Medical University of Silesia, Zabrze and 3Center of Pediatrics and Oncology, Chorzow, Poland
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  • and 2 IGOR OLEJNIK 3

    1. Departments of1Perinatology and Gynecology and 2Biochemistry, Medical University of Silesia, Zabrze and 3Center of Pediatrics and Oncology, Chorzow, Poland
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Barbara Królak-Olejnik, Department of Perinatology and Gynecology, Medical University of Silesia, PL. Traugutta 6, 41–800 Zabrze, Poland. Email: olejnik@pik-net.pl

Abstract

Background: The objective of this study was to explore the relationship between labor (preterm and term) and umbilical blood serum regulated on activation, normal T cell expressed and secreted (RANTES) and melanoma growth stimulatory activity/growth-related oncogene-a (MSGA/GRO-α) concentration, and to determine whether early sepsis and pneumonia are associated with changes in concentrations of the chemokines (RANTES and MSGA/GRO-α) in umbilical blood serum.

Methods: Umbilical blood was obtained from 67 neonates in the following groups: (i) preterm neonates with early sepsis; (ii) preterm neonates with pneumonia; (iii) non-infected preterm neonates; and (iv) full-term healthy neonates. RANTES and MGSA/GRO-α concentrations were determined by use of a commercially available immunoassay kit.

Results: Non-infected preterm neonates had lower RANTES concentrations than healthy term neonates. Preterm infected neonates (pneumonia or sepsis) did not have higher RANTES concentrations than non-infected preterm neonates. In contrast, non-infected preterm neonates had higher MSGA/GRO-α concentrations than full-term healthy neonates. And preterm neonates with sepsis had higher MGSA/GRO-α concentrations than preterm ones with pneumonia and non-infected preterm ones.

Conclusions: Preterm neonates had constitutively lower RANTES concentrations than term ones and it seems that during infection RANTES concentrations did not increase. MGSA/GRO-a concentrations were constitutively higher in preterm than term neonates, and septic events further increased its concentrations in preterm neonates.

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