Adjuvant effect of vitamin A on recurrent lower urinary tract infections
Article first published online: 22 MAY 2007
Volume 49, Issue 3, pages 310–313, June 2007
How to Cite
YILMAZ, A., BAHAT, E., YILMAZ, G. G., HASANOGLU, A., AKMAN, S. and GUVEN, A. G. (2007), Adjuvant effect of vitamin A on recurrent lower urinary tract infections. Pediatrics International, 49: 310–313. doi: 10.1111/j.1442-200X.2007.02370.x
- Issue published online: 22 MAY 2007
- Article first published online: 22 MAY 2007
- Received 1 February 2005; revised 27 January 2006; accepted 1 February 2006.
- urinary tract infection;
- vitamin A
Background: The purpose of the present paper was to investigate the effects of vitamin A supplementation on recurrent lower urinary tract infections (RUTI).
Methods: Twenty-four patients with non-complicated RUTI were included in a placebo-controlled, double-blinded study. Twelve patients received a single dose of 200 000 IU vitamin A in addition to antimicrobial therapy. Patient and control groups (each containing 12 patients) were followed for up to 1 year and were evaluated for eradication and frequency of lower urinary tract infections (UTI). Serum levels of vitamin A and β-carotene were determined periodically.
Results: During the first 6 months follow-up period the infection rate of the vitamin A-supplemented group reduced from 3.58 to 0.75 per 6 months, and in the subsequent 6 months the infection rate was 1.75 per 6 months. These values were calculated as 2.75, 2.83 and 2.66, respectively, in the placebo group.
Conclusion: Vitamin A supplementation may have an adjuvant effect on the treatment of RUTI.