Efficacy of vitamin E in children with immunotolerant-phase chronic hepatitis B infection

Authors

  • BUNYAMIN DIKICI,

    Corresponding author
    1. 1Department of Pediatrics, Abant Izzet Baysal University, Duzce Medical Faculty, Duzce, 2Department of Pediatrics, Dicle University Medical Faculty, 3Clinical Microbiology and Infectious Diseases, Kahramanmaras Sutcu Imam University, Medical Faculty, Diyarbakir, and 4Department of Pediatrics, Kafkas University Medical Faculty, Kars, Turkey
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  • 1 ABDULLAH DAGLI,

    1. 1Department of Pediatrics, Abant Izzet Baysal University, Duzce Medical Faculty, Duzce, 2Department of Pediatrics, Dicle University Medical Faculty, 3Clinical Microbiology and Infectious Diseases, Kahramanmaras Sutcu Imam University, Medical Faculty, Diyarbakir, and 4Department of Pediatrics, Kafkas University Medical Faculty, Kars, Turkey
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  • 2 HASAN UCMAK,

    1. 1Department of Pediatrics, Abant Izzet Baysal University, Duzce Medical Faculty, Duzce, 2Department of Pediatrics, Dicle University Medical Faculty, 3Clinical Microbiology and Infectious Diseases, Kahramanmaras Sutcu Imam University, Medical Faculty, Diyarbakir, and 4Department of Pediatrics, Kafkas University Medical Faculty, Kars, Turkey
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  • 3 MEKI BILICI,

    1. 1Department of Pediatrics, Abant Izzet Baysal University, Duzce Medical Faculty, Duzce, 2Department of Pediatrics, Dicle University Medical Faculty, 3Clinical Microbiology and Infectious Diseases, Kahramanmaras Sutcu Imam University, Medical Faculty, Diyarbakir, and 4Department of Pediatrics, Kafkas University Medical Faculty, Kars, Turkey
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  • and 4 AYDIN ECE 2

    1. 1Department of Pediatrics, Abant Izzet Baysal University, Duzce Medical Faculty, Duzce, 2Department of Pediatrics, Dicle University Medical Faculty, 3Clinical Microbiology and Infectious Diseases, Kahramanmaras Sutcu Imam University, Medical Faculty, Diyarbakir, and 4Department of Pediatrics, Kafkas University Medical Faculty, Kars, Turkey
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Bunyamin Dikici, MD, Department of Pediatrics, Abant Izzet Baysal University, Duzce Medical Faculty, 21180 Duzce, Turkey. Email: bdikici@dicle.edu.tr, bdikici@hotmail.com

Abstract

Background: The purpose of the present paper was to investigate the efficacy of vitamin E in children with immunotolerant-phase chronic hepatitis B virus (CHB) infection.

Methods: Fifty-eight immunotolerant children were prospectively and randomly recruited into two groups. Group 1 (study group) included 30 patients who received vitamin E at a dose of 100 mg/day throughout 3 months; group 2 (control group) contained 28 patients who did not receive any medication. Comparison of serological, virologic, and biochemical response ratios were done at the end of the therapy and after 6 months of vitamin E discontinuation.

Results: Mean alanine transaminase (ALT) values in group 1 at the beginning of the therapy, 3 months after the therapy initiation and 6 months after discontinuation were 30.4 ± 7.3 IU/L, 31.3 ± 7.8 IU/L and 32.1 ± 8.5 IU/L, respectively. The mean hepatitis B virus (HBV)-DNA load of group 1 at onset, and at the third and ninth months of the treatment were 3106 ± 718 pg/mL, 3530 ± 137 pg/mL and 3364 ± 1246 pg/mL, respectively. These changes in both ALT and HBV-DNA values did not reach significant levels (P > 0.05). In group 2, mean ALT values at the beginning of therapy, and at the third and ninth months were 28.0 ± 1.8 IU/L, 34.6 ± 8.1 IU/L, and 34.1 ± 7.0 IU/L, respectively (P > 0.05), and mean viral load of HBV-DNA was 4227 ± 1435 pg/mL, 3368 ± 2673 pg/mL, and 3018 ± 2814 pg/mL, respectively (P > 0.05). There was no statistically significant difference between group 1 and group 2 at the third and ninth months in the mean ALT values and viral load of HBV-DNA (P > 0.05). Hepatitis B s antigen and hepatitis B e antigen clearance or hepatitis B s antibody and hepatitis B e antibody seroconversion were not observed in either group.

Conclusion: As a first study investigating the effect of vitamin E in children with immunotolerant CHB infection, no beneficial effect could be demonstrated. Different immunomodulator protocols should be considered for future investigations.

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