Hyper-eosinophilia in granular acute B-cell lymphoblastic leukemia with myeloid antigen expression
Article first published online: 26 JUL 2012
© 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society
Volume 54, Issue 4, pages 543–546, August 2012
How to Cite
Kobayashi, D., Kogawa, K., Imai, K., Tanaka, T., Sada, A. and Nonoyama, S. (2012), Hyper-eosinophilia in granular acute B-cell lymphoblastic leukemia with myeloid antigen expression. Pediatrics International, 54: 543–546. doi: 10.1111/j.1442-200X.2011.03471.x
- Issue published online: 26 JUL 2012
- Article first published online: 26 JUL 2012
- Received 23 February 2011; revised 24 June 2011; accepted 29 August 2011.
- acute lymphoblastic leukemia;
- idiopathic hyper-eosinophilic syndrome;
- myeloid antigen
Acute lymphoblastic leukemia with eosinophilia (ALLEo) is a rare but a distinctive clinical entity. Clinical features of idiopathic hyper-eosinophilic syndrome (HES) can be seen in patients with ALLEo. We report a 10-year-old girl, in whom HES was initially suspected but further investigation confirmed the diagnosis of acute B-cell lymphoblastic leukemia with myeloid antigen expression. Clinical response to chemotherapy was excellent with achievement of complete remission for 4 years. Serum interleukin-3 and -5 were elevated at presentation and normalized with disappearance of eosinophilia after induction therapy, supporting the reactive nature of eosinophilia in ALLEo. Hematologic malignancy should be considered in patients with hyper-eosinophilia, before attributing it to HES.