Conflict of Interest Statement: Katsunori Fujii has no conflict of interest.
Acute disseminated encephalomyelitis following 2009 H1N1 influenza vaccine
Article first published online: 26 JUL 2012
© 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society
Volume 54, Issue 4, pages 539–541, August 2012
How to Cite
Fujii, K., Suyama, M., Chiba, K., Okunushi, T., Oikawa, J. and Kohno, Y. (2012), Acute disseminated encephalomyelitis following 2009 H1N1 influenza vaccine. Pediatrics International, 54: 539–541. doi: 10.1111/j.1442-200X.2011.03501.x
- Issue published online: 26 JUL 2012
- Article first published online: 26 JUL 2012
- Received 6 April 2011; revised 22 September 2011; accepted 7 October 2011.
- 2009 H1N1 influenza vaccination;
- acute disseminated encephalomyelitis;
Acute disseminated encephalomyelitis (ADEM) is an immune-mediated inflammatory disorder of the central nervous system. We describe a previously healthy 2-year-old boy with ADEM, who exhibited high fever, lethargy, and recurrent seizures at 25 days after H1N1 influenza vaccination. To our knowledge, there has been only one report of ADEM following the 2009 H1N1 influenza vaccine, although such vaccination is accompanied with optic neuritis apart from this case. Thus, this is the first case of ADEM without optic neuritis, following the 2009 H1N1 influenza vaccination. Although vaccine-associated ADEM remains rare, the increasing number of influenza vaccinations might increase the incidence of ADEM. We still need to pay attention to the occurrence of ADEM and treat patients with steroid therapy.