Fatigue in survivors of childhood acute lymphoblastic and myeloid leukemia in Japan
Article first published online: 13 FEB 2012
© 2011 The Authors. Pediatrics International © 2011 Japan Pediatric Society
Volume 54, Issue 2, pages 272–276, April 2012
How to Cite
Nagai, A., Zou, N., Kubota, M., Kojima, C., Adachi, S., Usami, I., Okada, M., Tanizawa, A., Hamahata, K., Matsubara, K., Higuchi, M. and Imaizumi, M. (2012), Fatigue in survivors of childhood acute lymphoblastic and myeloid leukemia in Japan. Pediatrics International, 54: 272–276. doi: 10.1111/j.1442-200X.2011.03530.x
- Issue published online: 16 APR 2012
- Article first published online: 13 FEB 2012
- Accepted manuscript online: 2 DEC 2011 07:25AM EST
- Received 4 June 2011; revised 16 September 2011; accepted 24 November 2011.
- acute lymphoblastic leukemia;
- acute myeloid leukemia;
- cancer survivor;
Background: Fatigue in cancer survivors is a serious problem in pediatric oncology, but reports on this issue are limited, especially in Asian countries.
Methods: Sixty-three patients with acute lymphoblastic leukemia and 18 patients with acute myeloid leukemia who attended a follow-up outpatient clinic were enrolled. Participants were required to be >8 years of age, in remission, and without any cancer treatment for at least the previous 1 year. A control group consisted of 243 subjects whose age and gender were matched with the patient group. A questionnaire consisting of 12 items was devised for fatigue measurement.
Results: Principal factor analysis identified three dimensions, defined as physical fatigue, decreased function, and altered mood. The mean total and the three fatigue dimension scores tended to be higher in the control group, but significant differences between the scores were seen only in the total and physical fatigue scores. Multiple regression analysis indicated an association of present older age or shorter duration after completion of treatment with total and physical fatigue, and an association of presence of total body irradiation with decreased function.
Conclusion: Pediatric leukemia survivors in Japan experience equal or less fatigue compared with that of controls in different fatigue dimensions. Elucidation of underlying mechanisms of cancer-related fatigue including the differences of cultural background among different countries is necessary for future study of this issue.