Insulin resistance at diagnosis in Japanese children with type 2 diabetes mellitus
Article first published online: 25 APR 2012
© 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society
Volume 54, Issue 4, pages 516–519, August 2012
How to Cite
Urakami, T., Habu, M., Kuwabara, R., Komiya, K., Nagano, N., Suzuki, J. and Mugishima, H. (2012), Insulin resistance at diagnosis in Japanese children with type 2 diabetes mellitus. Pediatrics International, 54: 516–519. doi: 10.1111/j.1442-200X.2012.03596.x
- Issue published online: 26 JUL 2012
- Article first published online: 25 APR 2012
- Accepted manuscript online: 23 FEB 2012 12:39PM EST
- Received 10 August 2011; revised 29 December 2011; accepted 31 January 2012.
- insulin resistance;
- percent overweight;
- type 2 diabetes mellitus
Background: Insulin resistance at diagnosis was investigated in Japanese children with type 2 diabetes mellitus (T2DM).
Methods: A total of 160 children with T2DM were divided into groups on the basis of percent overweight at time of diagnosis: group A (n= 28), <20%; group B (n= 55), 20–39%; group C (n= 37), 40–59%; group D (n= 40), ≥60%. Indicators of insulin resistance at diagnosis were compared among the four patient groups, and also between the children with T2DM and the 201 age-matched normal Japanese children.
Results: There were no significant differences in plasma glucose (PG) levels among the four patient groups. The mean concentration of fasting plasma immunoreactive insulin (IRI) was significantly higher in group D than in groups A and B (39.2 µU/mL vs 16.2 µU/mL and 24.1 µU/mL, P < 0.05, respectively). The mean homeostasis model assessment (HOMA-R) was significantly higher in group D than in all the other three groups (17.6 vs 7.8, 10.8 and 12.7, P < 0.05, respectively). The indicators HOMA-R and fasting IRI were significantly higher in each diabetes group, even in non-obese group A, than in normal children (P < 0.01, respectively).
Conclusions: Japanese children with T2DM had insulin resistance at diagnosis regardless of percent overweight, and the degree of insulin resistance gradually increased with rise in percent overweight.