Complementary findings in clinical and epidemiologic features of mumps and mumps meningoencephalitis in children without mumps vaccination

  1. Güler Kanra,
  2. Pinar Isik,
  3. Ates Kara,
  4. Ali Bülent Cengiz,
  5. Gülten Seçmeer,
  6. Mehmet Ceyhan

Article first published online: 22 DEC 2004

DOI: 10.1111/j.1442-200x.2004.01968.x

Issue

Pediatrics International

Pediatrics International

Volume 46, Issue 6, pages 663–668, December 2004

Additional Information

How to Cite

Kanra, G., Isik, P., Kara, A., Cengiz, A. B., Seçmeer, G. and Ceyhan, M. (2004), Complementary findings in clinical and epidemiologic features of mumps and mumps meningoencephalitis in children without mumps vaccination. Pediatrics International, 46: 663–668. doi: 10.1111/j.1442-200x.2004.01968.x

Author Information

  1. 1 Department of Pediatrics, Pediatric Infectious Disease Unit, Hacettepe University School of Medicine, Ankara and 2 Department of Pediatrics, Baskent University School of Medicine , Ankara, Turkey

* Professor Dr Güler Kanra, Hacettepe University School of Medicine, Department of Pediatrics, Pediatric Infectious Disease Unit, Hacettepe 06100, Ankara, Turkey. Email: ateskara@hacettepe.edu.tr

Publication History

  1. Issue published online: 22 DEC 2004
  2. Article first published online: 22 DEC 2004
  3. Received 11 December 2002; revised 16 January 2004; accepted 26 February 2004.

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Keywords:

  • children;
  • mumps meningoencephalitis;
  • mumps

Abstract

Background: Mumps vaccine has not yet been included in the routine vaccination programme, for this reason mumps is still one of the most common infections for children in Turkey. One of the major complication of mumps is meningoencephalitis, which although usually heals spontaneously, it may cause neurologic complications.

Methods: This study was undertaken to investigate epidemiologic and demographic characteristics in children with mumps and mumps meningoencephalitis and clinical/laboratory findings in children with mumps meningoencephalitis diagnosed over a 11 year period. A total of 2422 mumps and 135 mumps meningoencephalitis cases were covered in this study which constitutes one of the largest series of mumps meningoencephalitis in the literature. The mean age of mumps and mumps meningoencephalitis cases were 6.6 ± 2.7 and 7.6 ± 2.6 years, respectively.

Results: There was a male predominance both among the cases of mumps and mumps meningoencephalitis. The age and seasonal distributions were similar in the mumps and mumps meningoencephalitis groups. The most common symptoms of mumps meningoencephalitis were fever (97%), vomiting (94%) and headache (88.8%). The mean cerebrospinal fluid (CSF) total cell count and lymphocyte count were 540 ± 460/mm3 and 300 ± 330/mm3, respectively. The mean CSF protein and glucose levels were found to be 56.97 ± 27.94 mg/dL and 53.67 ± 15.46 mg/dL, respectively. The mean of CSF/blood glucose ratio was 0.53 ± 0.16. The mean duration of hospitalization in mumps meningoencephalitis cases was found to be 5.1 ± 2.4 days and this was longer in boys (P < 0.05).

Conclusion: In patients with mumps meningoencephalitis, higher CSF protein levels and lower CSF glucose/blood glucose ratio were associated with longer hospitalization periods. There was no death.

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