Significant Prognostic Factors for 5-Year Survival after Curative Resection of Renal Cell Carcinoma
Article first published online: 2 JUL 2007
International Journal of Urology
Volume 5, Issue 5, pages 418–422, September 1998
How to Cite
Masuda, H., Kurita, Y., Fukuta, K., Mugiya, S., Suzuki, K. and Fujita, K. (1998), Significant Prognostic Factors for 5-Year Survival after Curative Resection of Renal Cell Carcinoma. International Journal of Urology, 5: 418–422. doi: 10.1111/j.1442-2042.1998.tb00380.x
- Issue published online: 2 JUL 2007
- Article first published online: 2 JUL 2007
- Received Sep. 17, 1997; accepted for publication in revised form Mar. 19, 1998.
- renal cell carcinoma;
- prognostic factors;
- multivariate analysis
Background: Renal cell carcinoma (RCC) patients occasionally die of RCC even after curative resection. In this study, we investigated prognostic factors between survivors for more than 5 years and patients who died within 5 years after curative resection.
Methods: We retrospectively studied 111 patients who underwent RCC curative resection and were followed for more than 5 years. Patient survival at 5 years after curative resection was regarded as the end-point of this analysis. Statistical differences of 19 prognostic factors between surviving and deceased patients were determined using logistic regression analysis.
Results: Eighteen of the 111 patients died of RCC during the 5-year follow-up period. Of the 19 prognostic factors evaluated, univariate analysis showed significant differences in the body temperature, hemoglobin, erythrocyte sedimentation rate(ESR), α2-globulin, C-reactive protein (CRP), fibrinogen, tumor size, Robson's stage, T classification (renal capsular involvement), pathological grade, and mode of tumor infiltration. Five significant variables (body temperature, ESR, α2-globulin, fibrinogen, and tumor size) were excluded from multivariate analysis because greater than 10% of the data was missing. The TNM staging system was selected as the representative variable for stage for multivariate analysis. Using the remaining 5 significant variables (hemoglobin, CRP, T stage, pathological grade, and mode of tumor infiltration), multivariate analysis showed that CRP (P=0.01 26) and T stage (P=0.0490) were the most important prognostic factors.
Conclusion: From this analysis, CRP and renal capsular involvement were the most important factors predicting survival for greater than 5 years after curative resection of RCC.