Risk factors in past histories and familial episodes related to development of testicular germ cell tumor
Article first published online: 30 JUL 2004
International Journal of Urology
Volume 11, Issue 8, pages 640–646, August 2004
How to Cite
KANTO, S., HIRAMATSU, M., SUZUKI, K., ISHIDOYA, S., SAITO, H., YAMADA, S., SATOH, M., SAITO, S., FUKUZAKI, A. and ARAI, Y. (2004), Risk factors in past histories and familial episodes related to development of testicular germ cell tumor. International Journal of Urology, 11: 640–646. doi: 10.1111/j.1442-2042.2004.00853.x
- Issue published online: 30 JUL 2004
- Article first published online: 30 JUL 2004
- Received 30 July 2003; accepted 16 December 2003.
- inguinal hernia;
- testicular germ cell tumor
Abstract Background: A retrospective study was conducted to examine the host factors of 240 testicular germ cell tumor patients. This study was performed to address a new theory proposed by Skakkebaek called testicular dysgenesis syndrome which claims that cryptorchism, hypospadias, poor semen quality and testicular germ cell tumors are symptoms of an underlying testicular dysgenesis in uterus.
Methods: The past health histories and familial episodes of 240 testicular germ cell tumor patients were examined. The past health histories included cryptorchism, hypospadias, infertility, atrophic testis and inguinal hernia.
Results: Of the 240 patients, 13 (5.4%) had a history of cryptorchism or orchidopexy. Two (0.8%) showed existence of hypospadias or had experienced urethroplasty. Among 129 married couples, 104 (80.6%) couples were fertile. Three (1.3%) patients developed testicular tumors after they were diagnosed as infertile or came to the hospital with the complaints of infertility. Four (1.7%) had contralateral atrophic testis. 19 (7.9%) had experienced inguinal herniorrhaphy before age 15. Three (1.3%) had testicular germ cell tumor patients among their family or relatives.
Conclusions: The testicular germ cell tumor patients showed a considerable incidence of complications such as cryptorchism, hypospadias and incomplete closure of processus vaginalis. Cryptorchism, perinatal factors and familial factors could be risks for developing testicular germ cell tumors.