Long-term survival following radical prostatectomy in Japanese men with clinically localized prostate cancer: A single institutional study
Article first published online: 12 OCT 2004
International Journal of Urology
Volume 11, Issue 10, pages 862–869, October 2004
How to Cite
HACHIYA, T., OKADA, Y., KAWATA, N., HIRANO, D., YOSHIDA, T., OKADA, K. and TAKIMOTO, Y. (2004), Long-term survival following radical prostatectomy in Japanese men with clinically localized prostate cancer: A single institutional study. International Journal of Urology, 11: 862–869. doi: 10.1111/j.1442-2042.2004.00911.x
- Issue published online: 12 OCT 2004
- Article first published online: 12 OCT 2004
- Received 31 March 2003; accepted 16 March 2004.
- clinical progression-free survival;
- expected survival;
- prostate cancer-specific survival
Background: We evaluated the outcome of radical prostatectomy to provide information about long-term survival following this procedure.
Methods: One hundred and twenty-three otherwise healthy Japanese patients with clinically localized tumors underwent radical prostatectomy. Treatment outcomes were measured in terms of clinical progression-free survival, prostate cancer-specific survival and overall survival. Overall survival was compared with expected survival of age-matched Japanese men.
Results: For these 123 patients, clinical progression-free survival and prostate cancer-specific survival at 10 years were 72.5% and 86.4%, respectively. Results of Cox multivariate analysis showed that only pathological stage (P = 0.047) and tumor grade (P = 0.009) were independent predictors of clinical progression. Only tumor grade was a statistically significant independent predictor (P = 0.048) in terms of prostate cancer death. Both the 10 and 15-year overall survival rates for these 123 patients were 58.6%, whereas the expected survival of age-matched Japanese men was 65.0% at the 10-year follow up, and 43.8% at the 15-year follow up.
Conclusions: The long-term overall survival in this surgically treated group is comparable to the expected survival rate of age-matched Japanese men. These results might be useful in counselling patients with clinically localized prostate cancer.