Enhancement of T cell proliferative response against autologous cancer cells of a metasatic renal cell carcinoma patient after unexplained regression
Article first published online: 22 DEC 2004
International Journal of Urology
Volume 11, Issue 12, pages 1130–1132, December 2004
How to Cite
KAWAI, K., SAIJO, K., OIKAWA, T., OHNO, T. and AKAZA, H. (2004), Enhancement of T cell proliferative response against autologous cancer cells of a metasatic renal cell carcinoma patient after unexplained regression. International Journal of Urology, 11: 1130–1132. doi: 10.1111/j.1442-2042.2004.00954.x
- Issue published online: 22 DEC 2004
- Article first published online: 22 DEC 2004
- Received 12 August 2003; accepted 25 May 2004.
- cytotoxic T lymphocyte;
- idiopathic regression;
- renal cell carcinoma;
- T lymphocyte
Abstract The unexplained regression of a metastasis of renal cell carcinoma (RCC) is rare phenomenon. While an immune mechanism has been proposed for spontaneous or unexplained regression of RCC, only limited data are available regarding immunological response. We report a case of a 62-year-old man with RCC whose paravertebral pleural tumor regressed after the withdrawal of interferon-α. In the present case, we demonstrate the enhancement of T cell proliferative response against autologous RCC cells secondary to the unexplained regression using the mixed-lymphocyte tumor culture. To our knowledge, the enhancement of an antitumor immunity secondary to an unexplained regression of RCC has not previously been reported.