Kidney stone disease and risk factors for coronary heart disease
Version of Record online: 3 NOV 2005
International Journal of Urology
Volume 12, Issue 10, pages 859–863, October 2005
How to Cite
HAMANO, S., NAKATSU, H., SUZUKI, N., TOMIOKA, S., TANAKA, M. and MURAKAMI, S. (2005), Kidney stone disease and risk factors for coronary heart disease. International Journal of Urology, 12: 859–863. doi: 10.1111/j.1442-2042.2005.01160.x
- Issue online: 3 NOV 2005
- Version of Record online: 3 NOV 2005
- Received 26 August 2004; accepted 15 March 2005.
- calcium oxalate stone;
- coronary heart disease;
- risk factor
Abstract Background: We conducted a case-control study to examine the impact of coronal heart disease (CHD) risk factors on calcium oxalate (CaOX) stone formation.
Methods: Variables included body mass index (BMI), current alcohol use, smoking habit, hypertension, hypercholesterolemia, diabetes mellitus, and hyperuricemia. Data sufﬁcient for analysis were obtained for 181 CaOX stone formers and 187 controls.
Results: Seven of 181 stone formers (3.9%) had a history of CHD compared with none of 187 control subjects (P = 0.007). In univariate logistic regression analysis, smoking habit (OR 4.41, 95% CI 2.85–6.84, P < 0.0001), hypertension (OR 4.24, 95% CI 2.61–6.91, P < 0.0001), hypercholesterolemia (OR 3.03, 95% CI 1.77–5.20, P < 0.0001) and BMI (OR 1.10, 95% CI 1.04–1.17, P = 0.007) reached statistical signiﬁcance. In a multivariate logistic regression analysis, smoking habit (OR 4.29, 95% CI 2.68–6.86, P < 0.0001), hypertension (OR 3.57, 95% CI 2.11–6.07, P < 0.0001), and hypercholesterolemia (OR 2.74, 95% CI 1.51–5.00, P = 0.001) reached statistical signiﬁcance, while BMI (OR 1.06, 95% CI 0.99–1.12, P = 0.09) did not.
Conclusions: CaOX stone formers are signiﬁcantly associated with several CHD risk factors, including smoking habit, hypertension, hypercholesterolemia, and obesity.