Extensive biopsy using a combined transperineal and transrectal approach to improve prostate cancer detection
Version of Record online: 18 NOV 2005
International Journal of Urology
Volume 12, Issue 11, pages 959–963, November 2005
How to Cite
WATANABE, M., HAYASHI, T., TSUSHIMA, T., IRIE, S., KANESHIGE, T. and KUMON, H. (2005), Extensive biopsy using a combined transperineal and transrectal approach to improve prostate cancer detection. International Journal of Urology, 12: 959–963. doi: 10.1111/j.1442-2042.2005.01186.x
- Issue online: 18 NOV 2005
- Version of Record online: 18 NOV 2005
- Received 26 July 2004; accepted 20 May 2005.
- prostate-speciﬁc antigen;
- prostatic neoplasms
Purpose: Previous studies have indicated that 6-core transrectal prostate biopsy misses a considerable number of cancers. We performed an extensive biopsy protocol of 12-core sampling using both transperineal and transrectal approaches to determine the impact on the cancer detection rate.
Materials and methods: We prospectively evaluated 402 men who underwent 6-core transperineal and 6-core transrectal biopsies simultaneously due to abnormal digital rectal examination (DRE) and/or elevated prostate-speciﬁc antigen (PSA) levels of 4.0 ng/mL or greater. Using the transperineal approach we obtained four cores from the bilateral peripheral zone targeting the lateral and parasagittal areas and two cores from the bilateral transition zone. The following transrectal biopsy was performed traditionally. We compared cancer detection rate between the extended 12-core procedure and conventional 6-core transperineal and transrectal groups in terms of total PSA and DRE ﬁndings.
Results: Using the extensive combined method, prostate cancer was detected in 195 cases (48.5%) and the detection rate signiﬁcantly increased 7.2% and 8.5% compared to the transperineal and transrectal groups, respectively. According to PSA levels and DRE ﬁndings, the cancer detection rate by the combined method was signiﬁcantly improved in patients with PSA levels of 4–10 ng/mL and negative DRE: 10.3% and 11.6% compared to the transperineal and transrectal groups, respectively.
Conclusions: The extensive 12-core method signiﬁcantly improved the overall cancer detection rate and was especially efﬁcient for men with PSA levels of 4–10 ng/mL accompanied by a negative DRE ﬁnding.