Ipsilateral right testicular metastasis from renal cell carcinoma in a responder patient to interleukine-2 treatment
Article first published online: 10 APR 2007
International Journal of Urology
Volume 14, Issue 3, pages 259–260, March 2007
How to Cite
Camerini, A., Tartarelli, G., Martini, L., Donati, S., Puccinelli, P. and Amoroso, D. (2007), Ipsilateral right testicular metastasis from renal cell carcinoma in a responder patient to interleukine-2 treatment. International Journal of Urology, 14: 259–260. doi: 10.1111/j.1442-2042.2007.01674.x
- Issue published online: 10 APR 2007
- Article first published online: 10 APR 2007
- Received 19 December 2005; accepted 31 July 2006.
- renal cell carcinoma;
- testicular metastasis
Abstract: We present a case of metastatic spreading to the testicle in a 46-year-old patient with renal cell carcinoma, ‘clear-cell’ type, during interleukin-2 combined subcutaneous plus aerosol treatment. Testicular metastasis occurred while the patient showed a response to the treatment with disappearance of lung lesions and reduction of lymph-nodes lesions. After orchiectomy with spermatic cord resection and disease re-evaluation confirming the previous response, the patient re-started immunotherapy. The contrast between systemic disease response to treatment and disease testicular progression might be explained by a relative insensitivity of the testicle to interleukin-2 immunotherapy as a result of a possible establishment of an immunosuppressive microenvironment. We believe that the rarity of this metastatic site and the intriguing possible mechanisms at its base, makes an interesting case for clinicians.