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It is known that the opioid system is related to micturition control. This study showed that intracerebroventricular injection of mu- and delta 1-opioid agonists increased bladder capacity in rats with/without cerebral infarction and that kappa-opioid agonists increased bladder capacity in rats with cerebral infarction, but not without cerebral infarction. Although the mean bladder capacity in rats with cerebral infarction was about half of that in rats without cerebral infarction, recovery of bladder capacity by kappa-opioid agonists did not reach 100% in rats with cerebral infarction. Therefore, it is thought that other transmitters that are directly or indirectly related to the bladder capacity are decreased by cerebral infarction. In the future, the progression of research in this field is expected to bring about new treatment of neurogenic overactive bladder.