Grant Support: Funded in part by NIH grants #AG00745 and #AG17566 (DAS).
α1-Adrenoceptor subtypes and lower urinary tract symptoms
Article first published online: 26 FEB 2008
2008 The Japanese Urological Association
International Journal of Urology
Volume 15, Issue 3, pages 193–199, March 2008
How to Cite
Schwinn, D. A. and Roehrborn, C. G. (2008), α1-Adrenoceptor subtypes and lower urinary tract symptoms. International Journal of Urology, 15: 193–199. doi: 10.1111/j.1442-2042.2007.01956.x
- Issue published online: 26 FEB 2008
- Article first published online: 26 FEB 2008
- Received 9 August 2007; accepted 22 October 2007.
- alpha blockers;
- benign prostatic hyperplasia
Abstract: Benign prostatic hyperplasia (BPH) is a common cause of urinary outflow obstruction in aging men leading to lower urinary tract symptoms (LUTS). α1-Adrenoceptors (α1ARs) antagonists (blockers) have become a mainstay of LUTS treatment because they relax prostate smooth muscle and decrease urethral resistance, as well as relieving bladder LUTS symptoms. A review of key recent clinical trials suggests new insights into the role of specific α1AR subtypes in the treatment of LUTS.