Primary large cell neuroendocrine carcinoma of the urinary bladder
Article first published online: 8 DEC 2008
© 2008 The Japanese Urological Association
International Journal of Urology
Volume 15, Issue 12, pages 1080–1083, December 2008
How to Cite
Akamatsu, S., Kanamaru, S., Ishihara, M., Sano, T., Soeda, A. and Hashimoto, K. (2008), Primary large cell neuroendocrine carcinoma of the urinary bladder. International Journal of Urology, 15: 1080–1083. doi: 10.1111/j.1442-2042.2008.02168.x
- Issue published online: 8 DEC 2008
- Article first published online: 8 DEC 2008
- Received 3 May 2008; accepted 14 August 2008.
- large cell;
- small cell;
- urinary bladder
Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is rare. It is a type of neuroendocrine carcinoma morphologically distinct from small cell carcinoma. We report here a case of primary LCNEC of the urinary bladder. We observed a very large invasive tumor, which was not able to be detected three months previously by cystoscopy or computed tomography. The tumor cells morphologically and immunohistochemically resembled that of pulmonary LCNEC. With prompt cystoprostatectomy and chemotherapy, the patient is free of disease 16 months after diagnosis. Although LCNEC is usually very aggressive, it may be controlled by early diagnosis and treatment.