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This issue consists of two Perspectives in Urology, three Review Articles, five Original Articles, one Case Report, one Short Communication and two other reports. The content of this issue focuses on various interesting hot topics associated with clinical, as well as basic, aspects; therefore, I believe that this issue might help provide useful information for a wide variety of readers of IJU.

This issue starts with Perspectives in Urology, a newly introduced category in IJU, which briefly presents a scientific view of several fields of urology by specialists. Two articles published in this issue describe the application of gasless single-port surgery to partial nephrectomy by Kihara (Tokyo, Japan) and controversial issues in the decontamination process for urological endoscopes by Yanaihara et al. (Saitama, Japan).

This issue then includes three interesting Review Articles. Takenaka et al. (Tottori, Japan) summarized the recent progress in anatomical findings in relation to each basic step during robotic-assisted laparoscopic radical prostatectomy. They emphasized the important message that surgical anatomy should always be developing and changing with advances in surgical approaches. Matsumoto et al. (Asahikawa, Japan) described the pathophysiological relationship between metabolic syndrome and lower urinary tract symptoms (LUTS) with a special emphasis on bladder blood flow. They also proposed a novel therapeutic strategy for patients with LUTS from the viewpoint of bladder blood flow. Azuma et al. (Takatsuki, Japan) reviewed their experience of the development of novel bladder preservation approach for patients with locally advanced bladder cancer. They carried out combined therapy using balloon-occluded arterial infusion anticancer agents and hemodialysis with concurrent radiation, and presented promising oncological outcomes.

Consequently, five excellent Original Articles are provided. Jensen et al. (Aarhus, Denmark) compared the prognostic significance between extended and limited lymph node dissection in patients with bladder cancer who underwent radical cystectomy. Although extended nodal dissection provided more accurate staging than limited dissection, recurrence patterns appeared to be similar between these two groups. Shigemura et al. (Kobe, Japan) compared Wallace direct ureteroileal anastomosis with the Le Duc anti-reflux procedure in modified Studer orthotopic neobladder reconstruction after radical cystectomy. The authors concluded that direct ureteroileal anastomosis using the Wallace method is effective for minimizing the stenosis of ureteroileal anastomosis. Bayraktar et al. (Istanbul, Turkey) assessed the effect of constipation on serum prostate-specific antigen (PSA) levels in men. In this study, serum PSA values in the constipated patients before treatment were shown to be significantly higher than those in the control group; therefore, the authors recommended the re-evaluation of PSA value in the constipated patients before carrying out the prostate biopsy. Ip et al. (Taichung, Taiwan) reported the apoptotic effects of bee venom on human bladder cancer cells and the signaling pathways involved in this event. This article clearly showed the induction of both caspase-dependent and caspase-independent apoptotic cell death in human bladder cancer cells by bee venom through the intracellular Ca2+-modulated intrinsic death pathway. Nakane et al. (Gifu, Japan) analyzed the role of cortactin and silent mating type information regulation 2 homolog 1 (SIRT1) in migration and invasion of human prostate cancer DU145 cells. Because knockdown of cortaction or SIRT1 expression resulted in the inhibition of both migration and invasion of DU145 cells, the authors suggest that this strategy could be a promising treatment for prostate cancer by regulating its metastatic spread.

This issue also included an interesting Case Report and Short Communication. Fujisaki et al. (Shimotsuke-city, Japan) reported life-threatening anaphylaxis to leuprorelin acetate depot. Sugihara et al. (Iwata, Japan) reported the low incidence of admissions related to interstitial cystitis in Japan, which could possibly be explained by several factors, including racial difference, examination methods, lack of outpatient data and poor health-care coverage of this disease.

Conflict of interest

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  2. Conflict of interest

None declared.