These authors contributed equally to this work.
Original Articles Clinical Investigations
Murine double minute 2 promoter SNP309 polymorphism and prostate cancer risk: A meta-analysis
Article first published online: 21 JUN 2012
© 2012 The Japanese Urological Association
International Journal of Urology
Volume 19, Issue 10, pages 914–920, October 2012
How to Cite
Liu, G., Jiang, D., Shen, S. and Yu, L. (2012), Murine double minute 2 promoter SNP309 polymorphism and prostate cancer risk: A meta-analysis. International Journal of Urology, 19: 914–920. doi: 10.1111/j.1442-2042.2012.03067.x
- Issue published online: 23 SEP 2012
- Article first published online: 21 JUN 2012
- Received 23 December 2011; accepted 8 May 2012.; Online publication 21 June 2012
- murine double minute 2 SNP309;
- prostate cancer
Objective: The murine double minute 2 gene encodes a negative regulator of the tumor protein p53. A single nucleotide polymorphism in murine double minute 2 promoter, SNP309 T>G, has been reported to alter murine double minute 2 protein expression and to accelerate tumor formation in humans. We carried out a meta-analysis to explore the association between this polymorphism and prostate cancer risk.
Methods: All eligible studies were searched in PubMed. Crude odds ratios, with 95% confidence intervals, were assessed for the association using fixed- and random-effects models.
Results: Overall, five case–control studies (872 cases, 1005 controls) were included in the meta-analysis. A significant association between murine double minute 2 SNP309 and prostate cancer risk was observed for homozygote genetic model GG versus TT (odds ratio 0.72, 95% confidence interval 0.55–0.95, P < 0.05, P = 0.130 for heterogeneity), and for dominant model TG + GG versus TT (odds ratio 0.79, 95% confidence interval 0.65–0.96, P < 0.05, P = 0.119 for heterogeneity). The stratified analysis based on ethnicity showed a significant effect of the polymorphism on prostate cancer risk in Caucasians for GG versus TT.
Conclusions: Findings of the present meta-analysis suggest that the murine double minute 2 309 G allele might be associated with a reduced risk of prostate cancer. The effect of murine double minute 2 309 G allele on tumorigenesis might be influenced by sex and hormonal status.