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This issue covers a variety of practical topics and contains two Review Articles, eight Original Articles, two Short Communications, one Procedure and one Letter to the Editor.

Two reviews describe adverse events related to either targeted agents or contrast agents. Schmidinger et al. (Vienna, Austria) describe therapy management of cardiovascular adverse events in the context of targeted therapy for metastatic renal cell carcinoma. A multidisciplinary approach, and close collaboration between oncologists and cardiologists is essential for optimal management. Kitajima et al. (Kobe, Japan) review the adverse event in magnetic resonance imaging, nephrogenic systemic fibrosis, which is a progressive, potentially fatal, multiorgan system fibrosing disease related to exposure of patients with renal failure to gadolinium-based contrast agents. The researchers conclude that this disease can be eliminated by observing recent recommended guidelines.

Three of the eight Original Articles are related to prostate cancer.

Abdollah et al. (New York, USA) compare the mortality outcomes of radical prostatectomy and radiotherapy for patients with localized prostate cancer, and conclude that patients treated with radical prostatectomy fare substantially better than those treated with radiotherapy. Costantini et al. (Perugia, Italy) provide an Editorial Comment on this work.

Nomogram development and validation to predict the pathological stage of prostate cancer in the Asian population is reported by Jeong et al. (Seoul, Korea).

The correlation between cancer location and oncological outcome after radical prostatectomy is examined by Hashine et al. (Matsuyama, Japan), who observe that the cancer location and the occurrence of positive resection margins can have negative effects on recurrence-free survival.

Two Original Articles are related to urodynamics. Lee et al. (Houston, USA) report that transcorporal placement of an artificial urinary sphincter is both safe and efficacious in patients with a small caliber or atrophic urethra. Wu et al. (Chengdu, China) report that the Ras-related C3 botulinum toxin substrate 1 pathway is activated in mechanotransduction and regulation of human bladder smooth muscle cell proliferation in response to cyclic hydrodynamic pressure.

Two other articles are associated with postoperative systemic conditions, blood pressure and renal function. Wang et al. (Guangzhou, China) assess the blood pressure outcome in patients after adrenalectomy and Takagi et al. (Tokyo, Japan) assess the predictors of postoperative renal insufficiency after open partial nephrectomy, indicating two factors, lactase dehydrogenase and acute kidney injury.

Development of a patient-specific simulator for laparoscopic renal surgery, a practical training tool for surgeons, is reported by Makiyama et al. (Kanagawa, Japan).

In one of the two Short Communications, cytoreductive nephrectomy for pT3b–T4 M1 renal cell carcinoma is evaluated by Takagi et al. (Tokyo, Japan), who conclude that a higher pT stage and histological type are significant predictors for cancer-specific survival. Kawahara et al. (Kanagawa, Japan) evaluate preoperative stenting for ureteroscopic lithotripsy for a large renal stone.

In the Procedure, Kihara et al. (Tokyo, Japan) describe a new 3-D head-mounted display system that combines a high-definition 3-D organic electroluminescent head-mounted display with a high-definition 3-D endoscope to carry out minimally invasive surgery.

In a Letter to the Editor, Iwasaki et al. (Iwate, Japan) present a case of complete response to everolimus for treatment of metastatic renal cell carcinoma.

Conflict of interest

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  2. Conflict of interest

None declared.