Impact of pre-implant lower urinary tract symptoms on postoperative urinary morbidity after permanent prostate brachytherapy

Authors

  • Jun Teishima,

    Corresponding author
    1. Department of Urology, Integrated Health Sciences, Institute of Biochemical & Health Sciences, Hiroshima University, Hiroshima, Japan
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  • Hideo Iwamoto,

    1. Department of Urology, Integrated Health Sciences, Institute of Biochemical & Health Sciences, Hiroshima University, Hiroshima, Japan
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  • Katsutoshi Miyamoto,

    1. Department of Urology, Integrated Health Sciences, Institute of Biochemical & Health Sciences, Hiroshima University, Hiroshima, Japan
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  • Koichi Shoji,

    1. Department of Urology, Integrated Health Sciences, Institute of Biochemical & Health Sciences, Hiroshima University, Hiroshima, Japan
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  • Hiroshi Masumoto,

    1. Department of Urology, Integrated Health Sciences, Institute of Biochemical & Health Sciences, Hiroshima University, Hiroshima, Japan
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  • Shogo Inoue,

    1. Department of Urology, Integrated Health Sciences, Institute of Biochemical & Health Sciences, Hiroshima University, Hiroshima, Japan
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  • Kanao Kobayashi,

    1. Department of Urology, Integrated Health Sciences, Institute of Biochemical & Health Sciences, Hiroshima University, Hiroshima, Japan
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  • Mitsuru Kajiwara,

    1. Department of Urology, Integrated Health Sciences, Institute of Biochemical & Health Sciences, Hiroshima University, Hiroshima, Japan
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  • Akio Matsubara

    1. Department of Urology, Integrated Health Sciences, Institute of Biochemical & Health Sciences, Hiroshima University, Hiroshima, Japan
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Jun Teishima M.D., Ph.D., Department of Urology, Integrated Health Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minamiku, Hiroshima 734-8551, Japan. Email: teishimaj@yahoo.co.jp

Abstract

Objectives:  To assess the impact of baseline lower urinary tract symptoms on postoperative urinary morbidity in patients being treated for prostate cancer with 125-I permanent prostate brachytherapy.

Methods:  A total of 104 prostate cancer patients were enrolled in this study. Their urinary morbidity was followed up using the International Prostate Symptom Score and Expanded Prostate Cancer Index Composite for 12 months or more after permanent prostate brachytherapy. Patients were classified into two groups based on their baseline International Prostate Symptom Score: the low International Prostate Symptom Score group (score ≤ 7) and the high International Prostate Symptom Score group (score ≥ 8). Urinary morbidity was estimated in each group based on the results of the International Prostate Symptom Score and Expanded Prostate Cancer Index Composite measured before permanent prostate brachytherapy, and at 1, 3, 6, 9 and 12 months after the end of all radiation therapy.

Results:  The overall mean total International Prostate Symptom Score, International Prostate Symptom Score quality of life score, and urinary-related scores for Expanded Prostate Cancer Index Composite were significantly worse at 1 month after the end of treatment, but they improved gradually after the treatment and recovered to the baseline level within 12 months. Even in the high-International Prostate Symptom Score group, the International Prostate Symptom Score and International Prostate Symptom Score Quality of Life score were significantly worse at 1–3 months after permanent prostate brachytherapy, and then recovered to the baseline level without prolongation. Although the urination-related Expanded Prostate Cancer Index Composite score in the high-International Prostate Symptom Score group was significantly worse at 1 month after permanent prostate brachytherapy in comparison with that in the low-International Prostate Symptom Score group, it recovered to the baseline level without prolongation.

Conclusions:  The present findings suggest that the presence of lower urinary tract symptoms before implantation does not prolong urinary morbidity after permanent prostate brachytherapy.

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