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In this issue of the Journal, we have one Review Article, six Original Articles, one Case Report, two Short Communications and four Letters to the Editor.

This issue starts with an excellent Review Article on biochemical bone markers in prostate cancer with bone metastasis by Kamiya et al. (Sakura, Japan). The authors discussed the clinically relevant biomarkers of bone metabolism and the available evidence for their use in prostate cancer with bone metastasis. They described that N-terminal cross-linked telopeptide of type 1 collagen and bone-specific alkaline phosphatase are widely used bone metabolism markers, and offer reliable surrogate markers to detect bone metastatic spread and to predict prognosis for prostate cancer with bone metastasis.

Iizuka et al. (Tokyo, Japan) examined the medium-term functional outcomes of partial nephrectomy (PN) for cT1b renal cell carcinoma (RCC), and compared them with those of radical nephrectomy (RN) for cT1b and with those of PN for cT1a tumors. The authors showed that the higher anatomical complexity in cT1b tumors is unlikely to provide a significant influence on the residual renal function after PN compared with the tumors of cT1a. They explained that the results support the beneficial role of PN in the preservation of renal function of cT1b RCC patients undergoing surgery. Lightfoot et al. (Iowa City, USA) investigated whether random bladder and prostatic urethral biopsies, and individual upper tract cytologies (restaging) provide additional useful clinical detail to cystoscopy and bladder cytology in assessing intravesical therapy response for high-grade non-muscle invasive bladder cancer (NMIBC). The authors explained that approximately 25% of high-grade NMIBC early recurrences after induction intravesical therapy are missed without the addition of random and directed prostatic urethral biopsies, and isolated upper tract cytologies to standard cystoscopy and bladder cytology. Chiu et al. (Hualien, Taiwan) assessed overactive bladder (OAB) and its component symptoms in patients with type 2 diabetes mellitus (DM) and explored whether higher glycosylated hemoglobin (HbA1c) and other factors increase the risk of OAB symptoms. They indicated that patients with type 2 DM present more OAB symptoms/urgency and nocturia than controls, and a higher HbA1c level represents an independent predictor of OAB/urgency, urge urinary incontinence and nocturia in patients with type 2 DM. Heinonen et al. (Turku, Finland) evaluated the long-term outcome of the tension-free vaginal tape (TVT) procedure. The authors reported that the TVT procedure is effective and safe in stress urinary incontinence (SUI) patients even after 10 years, and the objective cure rate is high, but the subjective outcome is significantly lower in mixed urinary incontinence patients compared with pure SUI patients. Benbouzid et al. (Paris, France) explored the long-term outcome of transvaginal repair of pelvic organ prolapse (POP) using the Prolift system, a commercially available macroporous polypropylene mesh, after a minimal follow up of 3 years. The authors described that the Prolift system is safe and effective for POP repair by transvaginal approach after a 4.5-year follow up. Sanders et al. (Bonn, Germany) endeavoured to identify appropriate reference genes for the analysis of circulating microribonucleic acid (miRNA) in patients with urological malignancies. The authors found that SNORD43 is a suitable reference gene for the analysis of circulating miRNA in patients with urological malignancies.

We also have one Case Report and two Short Communications. Su et al. (Shanghai, China) reported an extremely rare case of adrenal myelolipoma associated with hyperandrogenemia. Chung et al. (Seoul, Korea) presented 4-year results from the Combination of Dutasteride and Tamsulosin (CombAT) study for Asian and Caucasian subpopulations. Batista et al. (São Paulo, Brazil) analyzed the glycosaminoglycans profile and heparanase expression in renal cell carcinoma in order to understand the molecular mechanisms of renal cell carcinogenesis.

We also have four Letters to the Editor by Kashima et al. (Tokyo, Japan), Li et al. (Nanjing, China), Ameda et al. (Sapporo, Japan) and Singh et al. (Lucknow, India). Their topics are pneumatosis intestinalis and hepatic portal venous gas in a patient receiving sorafenib, abdominal aortic transposition as a treatment alternative for posterior nutcracker syndrome, a case of AA amyloidosis of the bladder with interstitial cystitis, and response to advantages of self-tailored mesh for vaginal prolapse.

Conflict of interest

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  2. Conflict of interest

None declared.