An original article presented at:
Prognostic significance of body mass indices for patients undergoing esophagectomy for cancer
Version of Record online: 6 DEC 2006
Diseases of the Esophagus
Volume 20, Issue 1, pages 29–35, February 2007
How to Cite
Morgan, M. A., Lewis, W. G., Hopper, A. N., Escofet, X., Harvard, T. J., Brewster, A. E., Crosby, T. D. L., Roberts, S. A. and Clark, G. W. B. (2007), Prognostic significance of body mass indices for patients undergoing esophagectomy for cancer. Diseases of the Esophagus, 20: 29–35. doi: 10.1111/j.1442-2050.2007.00637.x
Association of Surgeons of GB and Ireland, Edinburgh 2006.
American Gastroenterology Association DDW, Los Angeles 2006.
- Issue online: 6 DEC 2006
- Version of Record online: 6 DEC 2006
- body mass index;
- esophageal cancer;
SUMMARY. The aim of this study was to determine the role of body mass index (BMI) in a Western population on outcomes after esophagectomy for cancer. Two hundred and fifteen consecutive patients undergoing esophagectomy for esophageal cancer of any cell type were studied prospectively. Patients with BMIs > 25 kg/m were classified as overweight and compared with control patients with BMIs below these reference values. Ninety-seven patients (45%) had low or normal BMIs, 86 patients (40%) were overweight, and a further 32 (15%) were obese. High BMIs were associated with a higher incidence of adenocarcinoma versus squamous cell carcinoma (83%vs. 14%, P = 0.041). Operative morbidity and mortality were 53% and 3% in overweight patients compared with 49% (P = 0.489) and 8% (P = 0.123) in control patients. Cumulative survival at 5 years was 27% for overweight patients compared with 38% for control patients (P = 0.6896). In a multivariate analysis, age (hazard ratio [HR] 1.492, 95% CI 1.143–1.948, P = 0.003), T-stage (HR 1.459, 95% CI 1.028–2.071, P = 0.034), N-stage (HR 1.815, 95% CI 1.039–3.172, P = 0.036) and the number of lymph node metastases (HR 1.008, 95% CI 1.023–1.158, P = 0.008), were significantly and independently associated with durations of survival. High BMIs were not associated with increased operative risk, and long-term outcomes were similar after R0 esophagectomy.