Contribution to the study: Débora Cerqueira Calderaro: selection and inclusion of patients, clinical interview and medical records review, and data collection and analysis. Marco Antônio Parreiras de Carvalho: selection and inclusion of patients, and data review. Luciana Dias Moretzsohn: esophageal manometries and data review.
Esophageal manometry in 28 systemic sclerosis Brazilian patients: findings and correlations
Article first published online: 31 JUL 2009
© 2009 Copyright the Authors. Journal compilation © 2009, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus
Diseases of the Esophagus
Volume 22, Issue 8, pages 700–704, November 2009
How to Cite
Calderaro, D. C., De Carvalho, M. A. P. and Moretzsohn, L. D. (2009), Esophageal manometry in 28 systemic sclerosis Brazilian patients: findings and correlations. Diseases of the Esophagus, 22: 700–704. doi: 10.1111/j.1442-2050.2009.01000.x
- Issue published online: 23 NOV 2009
- Article first published online: 31 JUL 2009
- esophageal motility disorder;
Systemic sclerosis (SSc) is a multisystem disease of unknown etiology. Esophageal involvement affects 50–90% of patients and is characterized by abnormal motility and hypotonic lower esophageal sphincter. Data on the association of esophageal abnormalities and age, gender, SSc subset or duration, autoantibody profile, esophageal symptoms, and medication are lacking or conflicting. The aim of this study was the evaluation of these associations in Brazilian sclerodermic patients from the Rheumatology Division, Clinics Hospital, Federal University, Minas Gerais. They underwent medical records review, clinical interview, and esophageal manometry. The normal cutoff level for lower esophageal sphincter pressure was 14 mmHg. Abnormal peristalsis occurred when less than 80% of peristaltic waves were propagated. P-values less than 0.05 were considered significant. Twenty-eight patients were included: 71% were women. The population presented medium age and disease duration of 46 years and 12 years, respectively. Cutaneous diffuse SSc occurred in 39% and its limited form in 61%. Dysphagia, pyrosis, and regurgitation occurred, respectively, in 71%, 43%, and 61% of patients. Lower esophageal sphincter pressure and number of peristaltic waves-propagated medias were, respectively, 17.2 mmHg and 2.3. SSc-related manometric abnormalities were present in 86% of patients. Manometry revealed distal esophageal body hypomotility, hypotonic lower esophageal sphincter, or both, respectively, in 82%, 39%, and 36% of patients. One patient presented the manometric pattern of esophageal achalasia. Male patients more frequently presented hypotonic inferior esophageal sphincter. Manometric findings have had no relationship with the other variables. Nifedipine use did not influence manometric findings.