Conflict of interests: Nothing to declare.
Esophageal manifestations of celiac disease
Article first published online: 25 MAR 2011
© 2011 Copyright the Author. Journal compilation © 2011, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus
Diseases of the Esophagus
Volume 24, Issue 7, pages 470–475, September 2011
How to Cite
Lucendo, A. J. (2011), Esophageal manifestations of celiac disease. Diseases of the Esophagus, 24: 470–475. doi: 10.1111/j.1442-2050.2011.01190.x
- Issue published online: 19 SEP 2011
- Article first published online: 25 MAR 2011
- celiac disease;
- eosinophilic esophagitis;
- gastroesophageal reflux;
- nonerosive reflux disease;
- peptic esophagitis
Celiac disease (CD) may often be associated with various motor disorders affecting the different segments of the digestive tract, including the esophagus. Although it has not been universally reported, some available evidences indicate that pediatric and adult celiac patients could manifest a higher frequency of esophagitis and gastroesophageal reflux disease-related symptoms compared to nonceliac patients. In addition, several published studies have consistently shown the efficacy of a gluten-free diet in rapidly controlling esophageal symptoms and in preventing their recurrence. Since the participation of gluten in the esophageal symptoms of CD seems clear, its intimate mechanisms have yet to be elucidated, and several hypothesis have been proposed, including the specific immune alterations characterizing CD, the reduction in nutrient absorption determining the arrival of intact gluten to distal gastrointestinal segments, and various dysregulations in the function of gastrointestinal hormones and peptides. Recent studies have suggested the existence of a possible relationship between CD and eosinophilic esophagitis, which should be more deeply investigated.