• esophageal neoplasm;
  • immunohistochemistry;
  • lymph node metastasis;
  • prognosis;
  • p21WAF1


The prognostic effect of p21WAF1 expression on esophageal squamous cell carcinoma patients is controversial. Further clarifying the effect of this protein is beneficial for optimizing the patient outcomes. In the current study, we investigated the expression of p21WAF1 protein in 189 specimens of stage III ESCC by immunohistochemistry. As shown by the Kaplan–Meier curve, the overall survival rate of the positive-expression group was significantly higher than that of the negative-expression group (P < 0.05). No significant correlation was observed between p21WAF1 expression and clinicopathological parameters in terms of gender, age, tumor location, tumor grade, pathological stage, and number of regional lymph node metastases (P > 0.05). We concluded that p21WAF1 played an intricate role in the tumorigenesis and development of ESCC. p21WAF1 could serve as a positive prognostic predictor for stage III ESCC patients.