Authorship: José M Remes-Troche performed the research, analyzed the data, and wrote the paper; Maura Torres-Aguilera performed the research, Gustavo Vazquez-Jimenez and Eli de la Cruz Patiño performed esophageal high resolution manometry.
Esophageal motor disorders in subjects with incidentally discovered Chagas disease: a study using high-resolution manometry and the Chicago classification
Article first published online: 22 OCT 2012
© 2012 Copyright the Authors. Journal compilation © 2012, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus
Diseases of the Esophagus
Volume 27, Issue 6, pages 524–529, August 2014
How to Cite
Remes-Troche, J. M., Torres-Aguilera, M., Antonio-Cruz, K. A., Vazquez-Jimenez, G. and De-La-Cruz-Patiño, E. (2014), Esophageal motor disorders in subjects with incidentally discovered Chagas disease: a study using high-resolution manometry and the Chicago classification. Diseases of the Esophagus, 27: 524–529. doi: 10.1111/j.1442-2050.2012.01438.x
Funding: This research was supported by grant M0034- FOMIX VERACRUZ 68427 from the National Science and Technology Council (CONACYT).
Portions of this work were presented at the 2009 Digestive Diseases Week, Chicago, Illinois, USA and published as an abstract in Gastroenterology 2009, 136 (Suppl 5): A327.
- Issue published online: 25 JUL 2014
- Article first published online: 22 OCT 2012
- National Science and Technology Council(CONACYT). Grant Number: M0034- FOMIX VERACRUZ 68427
- Chagas disease;
- EJG outflow obstruction;
- high-resolution manometry;
In patients with chronic indeterminate Chagas disease, conventional manometry has shown that 25–48% had esophageal motor disorders. Recently, esophageal high-resolution manometry (HRM) has revolutionized the assessment of esophageal motor function. In this study, we performed esophageal HRM in a group of subjects with incidentally positive serological findings for Trypanosoma cruzi. In this prospective observational study, we evaluated subjects who had positive serological tests for Chagas disease detected during a screening evaluation for blood donation. All subjects underwent symptomatic evaluation and esophageal HRM with a 36 solid-state catheter. Esophageal abnormalities were classified using the Chicago classification. Forty-two healthy subjects (38 males) aged 18–61 years (mean age, 40.7 years) were included. When specific symptoms questionnaire was applied, 14 (33%) subjects had esophageal symptoms. Esophageal high-resolution manometry revealed that 28 (66%) of the subjects had an esophageal motility disorder according to the Chicago classification. Most common findings were hypocontractile disorders in 18 subjects (43%) and esophagogastric junction (EGJ) outflow obstruction in 6 (15%). Esophageal high-resolution manometry reveals that up to two thirds of the subjects with an incidental diagnosis of Chagas disease have esophageal abnormalities. This technology increases the detection and allows a more complete assessment of esophageal motor function in subjects infected with T. cruzi even in the early stages of the disease.