Stretch-activated channels: a mini-review. Are stretch-activated channels an ocular barometer?


Correspondence: Professor Minas Coroneo, Department of Ophthalmology, Prince of Wales Hospital, University of New South Wales, High Street, Randwick, Sydney, NSW 2031, Australia. Email:


All cells are subject to physical forces by virtue of their position in a dynamically changing environment. This review outlines the various putative ‘mechanosensors’, or sensors of pressure cells possess, and discusses in particular the role stretch-activated membrane channels play in pressure recognition and transduction. The widespread occurrence of these channels is discussed and these ‘mechanosensors’ are related to pressure-related diseases, in particular, glaucoma.