Non-contiguous recurrence or secondary choroidal melanoma following plaque radiotherapy
Article first published online: 24 SEP 2007
Clinical & Experimental Ophthalmology
Volume 35, Issue 7, pages 657–660, September/October 2007
How to Cite
Maia, M., Pieramici, D. J., Eong, K.-G. A., Schachat, A. P., Rodrigues, E. B. and Green, W. R. (2007), Non-contiguous recurrence or secondary choroidal melanoma following plaque radiotherapy. Clinical & Experimental Ophthalmology, 35: 657–660. doi: 10.1111/j.1442-9071.2007.01531.x
- Issue published online: 24 SEP 2007
- Article first published online: 24 SEP 2007
- Received 23 January 2007; accepted 9 May 2007.
- non-contiguous recurrence;
- plaque radiotherapy;
- Uveal melanoma;
- vitreoretinal surgery
Non-contiguous local recurrence of posterior uveal melanoma occurs rarely after plaque therapy. A 50-year-old white first presented with choroidal melanoma. He underwent therapy with episcleral iodine-125 radioactive plaque therapy. Nine years later fundus evaluation revealed a new pigmented lesion in the inferotemporal equatorial area. Patient was considered to have a non-contiguous recurrent melanoma and the eye was enucleated. Histologic microscopic examination disclosed a 3 × 1.8 mm densely pigmented tumour internal to the choroid at the equator. The tumour was composed of large round cells with round nuclei, prominent nucleoli, abundant cytoplasm and spindle-shaped cells with spindle-shaped nuclei and prominent nucleoli. The tumour extended through the retina. The superior nasal area of plaque therapy had extensive chorioretinal atrophy with loss of retinal pigment epithelium, thinning of the retina and thinning and depigmentation of the choroids. Within this area of atrophy, there was a pigmented lesion composed by densely packed, spindle-shaped cells with spindle-shaped nuclei. Our patient illustrated non-contiguous recurrence of choroidal melanoma, such finding raises concerns about physiopathology and treatment of choroidal melanoma.