Comparison of posterior capsule opacification in rabbits receiving either mitomycin-C or distilled water for sealed-capsule irrigation during cataract surgery
Article first published online: 8 NOV 2007
Clinical & Experimental Ophthalmology
Volume 35, Issue 8, pages 755–758, November 2007
How to Cite
Kim, S.-Y., Kim, J.-H., Choi, J.-S. and Joo, C.-K. (2007), Comparison of posterior capsule opacification in rabbits receiving either mitomycin-C or distilled water for sealed-capsule irrigation during cataract surgery. Clinical & Experimental Ophthalmology, 35: 755–758. doi: 10.1111/j.1442-9071.2007.01588.x
- Issue published online: 8 NOV 2007
- Article first published online: 8 NOV 2007
- Received 6 April 2007; accepted 25 July 2007.
- posterior capsule opacification;
- sealed-capsule irrigation
Purpose: To compare posterior capsule opacification (PCO) in rabbits who undergo cataract surgery and receive either mitomycin-C (MMC) or distilled water (DW) during sealed-capsule irrigation (SCI). In addition, we examined the toxicity of DW and MMC.
Methods: Twenty-four eyes from 12 rabbits were divided into three groups. Balanced salt solution (BSS), DW, MMC 0.4 mg/mL was injected into the capsular bag for 2 min after endocapsular phacoemulsification and insertion of a SCI device. The degree of PCO was assessed by POCOman software at 3 months post surgery. Central corneal thickness, anterior chamber inflammation were assessed 1 day, 1 week, 2 weeks, 3 weeks, 1 month and 3 months postoperatively.
Results: A statistically significant difference in PCO scores was noted between the control and study groups (P < 0.05). The PCO scores of the MMC group were significantly lower than those of the DW group (P < 0.05). The MMC and DW groups did not show significant toxicity compared with the BSS group.
Conclusions: MMC is more effective in reducing PCO than DW; the SCI device can protect the surrounding ocular tissue from MMC toxicity in rabbit eyes.