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Risk factors for primary open-angle glaucoma in a Burmese population: the Meiktila Eye Study

Authors

  • Robert J Casson FRANZCO,

    Corresponding author
    1. South Australian Institute of Ophthalmology and Department of Ophthalmology and Visual Sciences, Adelaide University, Adelaide, South Australia, Australia; and
      Associate Professor Robert Casson, South Australian Institute of Ophthalmology, Department of Ophthalmology and Visual Sciences, Adelaide University, South Australia 5000, Australia. E-mail: robert.casson@adelaide.edu.au
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  • Aanchal Gupta MBBS,

    1. South Australian Institute of Ophthalmology and Department of Ophthalmology and Visual Sciences, Adelaide University, Adelaide, South Australia, Australia; and
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  • Henry S Newland FRANZCO,

    1. South Australian Institute of Ophthalmology and Department of Ophthalmology and Visual Sciences, Adelaide University, Adelaide, South Australia, Australia; and
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  • Steve McGovern FRANZCO,

    1. South Australian Institute of Ophthalmology and Department of Ophthalmology and Visual Sciences, Adelaide University, Adelaide, South Australia, Australia; and
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  • James Muecke FRANZCO,

    1. South Australian Institute of Ophthalmology and Department of Ophthalmology and Visual Sciences, Adelaide University, Adelaide, South Australia, Australia; and
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  • Dinesh Selva FRANZCO,

    1. South Australian Institute of Ophthalmology and Department of Ophthalmology and Visual Sciences, Adelaide University, Adelaide, South Australia, Australia; and
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  • Than Aung MD

    1. Yangon Eye Hospital, Yangon, Myanmar
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Associate Professor Robert Casson, South Australian Institute of Ophthalmology, Department of Ophthalmology and Visual Sciences, Adelaide University, South Australia 5000, Australia. E-mail: robert.casson@adelaide.edu.au

Abstract

Purpose:  To report the risk factors associated with primary open-angle glaucoma (POAG) in the Burmese population.

Methods:  The Meiktila Eye study, a population-based cross-sectional study, included inhabitants 40 years of age and over from villages in the Meiktila District. Of 2481 eligible participants identified, 2076 participated in the study and sufficient examination data to diagnose glaucoma in at least one eye was obtained in 1997 participants. The ophthalmic examination included slit-lamp examination, tonometry, gonioscopy and dilated stereoscopic fundus examination. Definitions adhered to the International Society for Geographic and Epidemiological Ophthalmology's recommendations. Univariate and multivariate analyses of potential risk factors were performed.

Results:  The overall prevalence of POAG was 2.0% (95% CI 0.9–3.1). In the univariate analysis, increasing age (P = 0.024), spherical equivalent (P = 0.01), axial length (P = 0.023) and intraocular pressure (IOP; P < 0.001) were significantly associated with POAG. And in the multivariate analysis, myopia <0.5 D (P = 0.049), increasing age and IOP (P < 0.001) were significant risk factors for POAG.

Conclusion:  POAG in this Burmese population was associated with increasing age, axial myopia and IOP.

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