Comparison of the corneal endothelial protective effects of Healon-D and Viscoat

  1. Carolee M Cutler Peck MD MPH1,
  2. Zachary P Joos BA3,
  3. Brian E Zaugg BS2,
  4. Salwa Abdel-Aziz MD MPH1,
  5. Jack D Stringham BS2,
  6. Liliana Werner MD PhD1,*,
  7. Nick Mamalis MD1,
  8. Randall J Olson MD1

Article first published online: 18 MAR 2009

DOI: 10.1111/j.1442-9071.2009.02034.x

Issue

Clinical & Experimental Ophthalmology

Clinical & Experimental Ophthalmology

Volume 37, Issue 4, pages 397–401, May/June 2009

Additional Information

How to Cite

Peck, C. M. C., Joos, Z. P., Zaugg, B. E., Abdel-Aziz, S., Stringham, J. D., Werner, L., Mamalis, N. and Olson, R. J. (2009), Comparison of the corneal endothelial protective effects of Healon-D and Viscoat. Clinical & Experimental Ophthalmology, 37: 397–401. doi: 10.1111/j.1442-9071.2009.02034.x

Author Information

  1. 1

    John A. Moran Eye Center, University of Utah,

  2. 2

    University of Utah School of Medicine, Salt Lake City, Utah, and

  3. 3

    Creighton University School of Medicine, Omaha, Nebraska, USA

*Dr Liliana Werner, John A. Moran Eye Center, University of Utah, 65 No., Mario Capecchi Drive, Salt Lake City, UT 84132, USA. Email: liliana.werner@hsc.utah.edu

Publication History

  1. Issue published online: 30 JUN 2009
  2. Article first published online: 18 MAR 2009
  3. Received 19 November 2008; accepted 4 February 2009.

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Keywords:

  • animal study;
  • corneal endothelium;
  • phaco-emulsification;
  • viscoelastics

Abstract

Background:  The use of dispersive ophthalmic viscosurgical devices (OVDs) has been shown to provide significant protection against air bubble damage to the corneal endothelium when compared with cohesive OVDs. We compared the corneal endothelial protective effects of a new dispersive OVD, Healon-D, with Viscoat.

Methods:  Healon-D and Viscoat were used in a randomized and masked fashion in the anterior chamber of 40 rabbit eyes during a procedure where ultrasound at 70% continuous energy was delivered for 2 min. Two millilitres of air bubbles were injected into the anterior chamber during the first minute of the procedure on each eye. Corneas were then stained with trypan blue and alizarin red and evaluated via light microscopy for endothelial injury. Both denuding of the endothelial layer, as well as damage to endothelial cells were quantified by using the Evaluation of Posterior Capsule Opacification digital imaging system.

Results:  The denuded area for eyes treated with Healon-D and Viscoat were not significantly different (medians of 0.004167and 0.003333, respectively, P = 0.8908). There was no significant difference in the area of endothelial cell damaged (medians of 0.02183 and 0.01433, respectively, P = 0.4565). When the denuded and damaged areas were calculated together, there was also no difference in the total injured area (medians of 0.05817 and 0.05821, respectively, P = 0.5740).

Conclusion:  The new dispersive OVD Healon-D is equally as effective as Viscoat in protecting the corneal endothelial layer from denuding and damage from air bubbles during anterior segment surgery.

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