Conflict/competing interest: No stated conflict of interest.
Visual function following photodynamic therapy for central serous chorioretinopathy: a comparison of automated macular microperimetry versus best-corrected visual acuity
Article first published online: 19 SEP 2011
© 2011 The Authors. Clinical and Experimental Ophthalmology © 2011 Royal Australian and New Zealand College of Ophthalmologists
Clinical & Experimental Ophthalmology
Volume 40, Issue 1, pages e32–e39, January/February 2012
How to Cite
Ehrlich, R., Mawer, N. P., Mody, C. H., Brand, C. S. and Squirrell, D. (2012), Visual function following photodynamic therapy for central serous chorioretinopathy: a comparison of automated macular microperimetry versus best-corrected visual acuity. Clinical & Experimental Ophthalmology, 40: e32–e39. doi: 10.1111/j.1442-9071.2011.02654.x
Funding sources: No specific funding.
- Issue published online: 5 FEB 2012
- Article first published online: 19 SEP 2011
- Accepted manuscript online: 11 JUL 2011 06:26AM EST
- Received 25 March 2011; accepted 23 June 2011.
- central serous chorio retinopathy;
- photodynamic therapy
Background: The study compares the change in best-corrected visual acuity with the change in central retinal sensitivity before treatment and 6 months after treatment with photodynamic therapy in patients with symptomatic central serous chorio retinopathy.
Design: Prospective, single-centre, interventional case series.
Participants: Eleven consecutive patients with previously untreated central serous chorio retinopathy.
Methods: Patients had microperimetry and best-corrected visual acuity recorded before and 6 months after treatment with photodynamic therapy. Refracted best-corrected visual acuity was assessed at 2 m and adjusted to give the number of letters read at 1 m. Threshold microperimetry was performed by presenting a Goldman III stimulus to 29 points over the central 12° around fixation. Significant visual improvement at 6 months was defined as a best-corrected visual acuity ≥10 letters or, microperimetry change in mean retinal sensitivity ≥2 decibels (dB).
Main Outcome Measures: Improvement in best-corrected visual acuity compared with microperimetry following photodynamic therapy treatment in patients with central serous chorio retinopathy.
Results: All patients reported a subjective improvement in vision and had complete resolution of subretinal fluid at 6 months. Two patients had a significant improvement in best-corrected visual acuity (mean ± SD +4.2 ± 5.8 letters), compared with all 11 patients who recorded a significant improvement in mean retinal sensitivity (mean ± SD 4.6 ± 1.9 dB) (P < 0.001).
Conclusions: These data suggest that compared with microperimetry, best-corrected visual acuity is underestimating the effectiveness of photodynamic therapy in the treatment of central serous chorio retinopathy.