Competing/conflicts of interest: No stated conflict of interest.
Singapore Malay Eye Study: rationale and methodology of 6-year follow-up study (SiMES-2)
Article first published online: 27 MAR 2012
© 2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists
Clinical & Experimental Ophthalmology
Volume 40, Issue 6, pages 557–568, August 2012
How to Cite
Rosman, M., Zheng, Y., Wong, W., Lamoureux, E., Saw, S.-M., Tay, W.-T., Wang, J. J., Mitchell, P., Tai, E.-S. and Wong, T. Y. (2012), Singapore Malay Eye Study: rationale and methodology of 6-year follow-up study (SiMES-2). Clinical & Experimental Ophthalmology, 40: 557–568. doi: 10.1111/j.1442-9071.2012.02763.x
Funding sources: This study was supported by the National Medical Research Council Grants no. 0796/2003 and Biomedical Research Council Grant no. 501/1/25-5.
- Issue published online: 13 AUG 2012
- Article first published online: 27 MAR 2012
- Accepted manuscript online: 2 FEB 2012 11:58AM EST
- Received 13 August 2011; accepted 4 December 2011.
- epidemiological study;
- follow-up study;
- Singaporean Malays
Background: To describe the rationale and study design of a follow-up epidemiological eye study among Singaporean Malay adults.
Design: Follow-up prospective population-based study.
Participants: Participants of the Singapore Malay Eye Study (SiMES-1), which was conducted from August 2004 to June 2006.
Methods: This is a follow-up study of the 3280 participants who participated in the SiMES-1 and are residing in Singapore. All participants of this follow-up study will undergo various standardized validated questionnaires on socio-demographics, quality of life and impact of visual impairment. Participants will undergo assessment of blood pressure, anthropometry, presenting and best corrected visual acuity, subjective refraction, ocular biometry, slit lamp and dilated eye examination, Goldmann tonometry, optic disc imaging, digital lens and retinal photography. Retinal tomography, retinal optical coherence topography and fundus autofluorescence will also be performed. Gonioscopy and visual fields examination will be performed on selected individuals.
Main Outcome Measures: Incidence, risk factors and impact of visual impairment and major eye diseases.
Results: A total of 3280 people who participated in the SiMES-1 will be contacted and invited to participate in this follow-up study. It is estimated that 12.8% of the participants will be deceased and there will be an 80% participation rate for the survivors of SiMES-1 (approximately 2288 participants).
Conclusion: SiMES-2 will be one of the few follow-up epidemiological eye studies among Asians and will determine the cumulative 6-year incidence, progression, risk factors and impact of major eye diseases in Singaporean Malay adults.