Asian age-related macular degeneration phenotyping study: rationale, design and protocol of a prospective cohort study

Authors

  • Chui Ming G Cheung FRCOphth,

    Corresponding author
    1. Singapore National Eye Centre
    2. Singapore Eye Research Institute
      Dr Chui Ming Gemmy Cheung, Singapore Eye Research Institute, Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751. Email: gemmy.cheung.c.m@snec.com.sg
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  • Mayuri Bhargava FRCS,

    1. Singapore National Eye Centre
    2. Singapore Eye Research Institute
    3. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore
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  • Augustinus Laude FRCSEd,

    1. Singapore Eye Research Institute
    2. Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital
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  • Adrian CH Koh FRCOphth,

    1. Singapore Eye Research Institute
    2. Eye and Retinal Surgeons, Camden Medical Centre, Singapore
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  • Li Xiang PhD,

    1. Singapore Eye Research Institute
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  • Doric Wong FRCSEd,

    1. Singapore National Eye Centre
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  • Thet Niang FRCSEd,

    1. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore
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  • Tock Han Lim FRCSEd,

    1. Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital
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  • Lingam Gopal FRCSEd,

    1. Singapore Eye Research Institute
    2. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore
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  • Tien Y Wong MD PhD

    1. Singapore National Eye Centre
    2. Singapore Eye Research Institute
    3. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore
    4. Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
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  • Competing/conflicts of interest: No stated conflict of interest.

  • Funding sources: National Medical Research Council grant: NMRC/NIG/1003/2009.

Dr Chui Ming Gemmy Cheung, Singapore Eye Research Institute, Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751. Email: gemmy.cheung.c.m@snec.com.sg

Abstract

Background:  Current knowledge of the phenotypic characteristics (e.g. clinical features, risk factors, natural history and treatment response) of age-related macular degeneration (AMD) in Asians remains limited. This report summarizes the rationale and study design of a prospective observational study of Asian neovascular AMD, including polypoidal choroidovasculopathy variant.

Design:  The Asian AMD phenotyping study is a prospective, observational clinical study of Asian patients with neovascular AMD or polypoidal choroidovasculopathy in three tertiary eye centres in Singapore.

Participants:  The study aims to recruit 500 consecutive patients from the retinal clinics of three tertiary eye centres in Singapore.

Methods:  Standardized examination procedures include interviews, a comprehensive eye examination, digital photography of the retina, fundus fluorescein and indocyanine green angiography and spectral domain optical coherence tomography using a standardized protocol. Blood samples were collected for biochemical analyses and stored for genetic and proteomic studies.

Main Outcome Measures:  The aim of the study was to build a comprehensive database of clinical, angiographic, functional and natural history data of Asian AMD over a 12-month follow-up period.

Results:  This article discusses the methodology and design of this prospective multi-centred study.

Conclusion:  This study will provide in-depth longitudinal data of the evolution of clinical features, risk factors, natural history and treatment pattern and response of Asian AMD and polypoidal choroidovasculopathy, allowing unique insights into pathogenesis and the design of new treatment strategies.

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